神光源颗粒剂长期毒性实验研究  

Long Term Toxicity Test for Shenguangyuan Granule

作　　者：梁学政[1] 吴西西[1] 黄仁彬[2] 黄志明[2] 陈美芳[2] 林军[2] 

机构地区：[1]柳州市中医院,广西柳州545001 [2]广西医科大学药理教研室,广西南宁530021

出　　处：《广西中医学院学报》2004年第3期11-13,共3页Journal of Guangxi Traditional Chinese Medical University

基　　金：广西科技厅科技攻关项目 (编号 :992 0 0 2 3) ;广西卫生厅基金资助项目 (合同号 :9936 )

摘　　要：[目的 ]观察大鼠长期给予神光源颗粒剂是否产生毒性反应。 [方法 ]神光源颗粒剂以其提取的浸膏给药 ,小、中、大剂量组分别按 3 6 g/kg ,7 2 g/kg ,14 4 g/kg连续灌胃 6个月 ,分别相当于临床用量的 2 0倍、4 0倍、80倍。于给药 6个月时检测大鼠的体重、血液量、生化指标 ,测量心、肝、脾、肺、肾、脑、睾丸、子宫等脏器系数 ,对各脏器组织进行病理学检查。 [结果 ]神光源颗粒剂各剂量组各项指标均未见明显异常改变。 [结论 ]大鼠长期服用神光源颗粒剂安全无毒。To investigate whether long term administration of Shenguangyuan granule to rats has toxicity. The Wistar rats were divided into three groups, and the dosage of 3.6g/kg, 7.2g/kg, and 14.48g/kg were perfused respectively to the three groups for 6 months. These dosages were 20,40 and 80 times more than the clinical dosages respectively. 6 months later after discontinuation, all the body weights, hematological or biochemical indexes, both relative weight and morphologies of heart, liver, spleen, lung, kidney, brain, testis and uterus were tested.No evident abnormal change of every index was observed in every group.[Conclusion]Long term administration of Shenguangyuan granule to rats was safe.

关 键 词：神光源颗粒剂 毒理实验 大鼠 

分 类 号：R285.5[医药卫生—中药学]