微生物检定法在抗生素质控分析中的应用  

Application of the Microbiological Method in Examining the Quality of Antibiotics

作　　者：李霞 

机构地区：[1]重庆市药品检验所,重庆400015

出　　处：《中国药业》2004年第9期21-23,共3页China Pharmaceuticals

摘　　要：目的:分析微生物检定法在抗生素质控分析中的应用进展。方法:从抗生素的常量分析(抗生素成品及抗生素工业生产中间品的质量控制)和微量分析(体内抗生素的分析及一些物质中残留抗生素的分析)这两方面对微生物检定法的应用情况进行了论述。结果:微生物检定法在抗生素的含量测定中所占比例大幅度降低。结论:微生物检定法在抗生素的常量分析和微量分析中均是一种最常规的检测方法,但逐渐被高效液相色谱法取代已是发展趋势。Objective:To discuss the evolution that apply microbiological assay to examine the quality of antibiotics.Methods:Application of the microbiological assay was discussed from usual quantity analysis and minimum quantity analysis of antibiotics.Results:Application of the microbiological assay is greatly receding in quantity analysis of antibiotics.Conclusion:The method for microbiological assay is a general technique in usual quantity analysis and minimum quantity analysis of antibiotics,but it's a trend that the microbiological assay is gradually replaced by HPLC.

关 键 词：微生物检定法 抗生素 质控分析 高效液相色谱法 

分 类 号：R927[医药卫生—药学]