2型糖尿病患者肺功能变化及其相关因素探讨  

Pulmonary Function in Type 2 Diabetes and Its Related Factors

作　　者：余红缨[1] 张妍[2] 毕会民[2] 

机构地区：[1]武汉大学人民医院呼吸内科,武汉430060 [2]武汉大学人民医院内分泌科,武汉430060

出　　处：《武汉大学学报（医学版）》2004年第5期552-553,556,共3页Medical Journal of Wuhan University

摘　　要：目的 :观察 2型糖尿病患者肺功能变化并分析其影响因素。方法 :测定 70例 2型糖尿病患者和 5 0例正常对照组的肺功能 ,同时对糖尿病组肺功能变化进行多因素线性相关分析。结果 :糖尿病组肺活量 (VC)、1秒钟用力呼气容积 (FEV1)、最大通气量 (MVV)、肺总量 (TLC)、肺一氧化碳弥散量 (DLco)均明显低于对照组 (P <0 .0 5或P<0 .0 1)。多因素线性回归分析表明VC、MVV、TLC与病程、糖化血红蛋白 (HbA1c)、并发症积分、胰岛素抵抗指数(HOMA IR)、身高体重指数 (BMI)无显著相关 ;FEV1与并发症积分呈显著相关 (P <0 .0 5 ) ,DLco与HbA1c、并发症积分及HOMA IR呈显著相关 (分别为P <0 .0 5 ,P <0 .0 1)。结论 :2型糖尿病患者存在肺通气及肺弥散功能障碍 ,控制血糖改善胰岛素抵抗使其防治重点。Objective: To explore the change of pulmonary function in type 2 diabetes and to investigate its related factors.Methods: The pulmonary function of 70 type 2 diabetes and 50 healthy objects were measured. The related factors of type 2 diabetes (pathological progress,HbA1c,complication integra,HOMA-IR,BMI)were analysed with liner regression analysis. Results: Vital capacity(VC), forced expiratory volume in first second (FEV 1 ), maximal voluntary ventilation(MVV), maximal voluntary ventilation(TLC) and diffusion capacity for carbon monoxide of lung(Dlco) were significantly decreased. Liner regression analysis showed that FEV 1 was negatively correlated with complication integra, while DLco was negatively correlated with HbA1c and HOMA-IR. Conclusion: Type 2 diabetes have abnormalities of pulmonary ventilatory function and diffusive function.Glycemic control and ameliorating insulin resistance is important for the prevention and cure.

关 键 词：糖尿病 肺功能 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]