活血通脉片对心绞痛病人血浆内皮素和降钙素基因相关肽的影响  

Effect of HXTMT on Serum ET and CGRP in Angina Patients

作　　者：丁家望[1] 朱良英 李松[1] 李稳慧[1] 杨俊[1] 席祖洋[1] 张朝晖[1] 

机构地区：[1]三峡大学第一临床医学院 [2]湖北省宜都市松宜煤炭矿务局疗养院

出　　处：《中西医结合心脑血管病杂志》2004年第9期502-503,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的　观察活血通脉片对心绞痛病人血浆内皮素和降钙素基因相关肽的影响。方法　 60例病人随机分为活血通脉片组 (3 0例 ,常规西药加活血通脉片 )与单纯西药治疗组 (3 0例 ,单用西药治疗 ) ,观察治疗前后血浆内皮素 (ET)与降钙素基因相关肽 (CGRP)含量、临床症状和心电图的变化 ,并与 2 0例健康人作对比。结果　治疗前两组病人ET明显高于健康人 (P <0 .0 1) ,CGRP明显低于健康人 (P <0 .0 1) ,治疗后两组病人ET均明显降低 ,CGRP均明显升高 ,但是活血通脉组明显优于西药对照组(P <0 .0 1) ,活血通脉组临床疗效总有效率及心电图疗效总有效率明显优于西药对照组 (P <0 .0 1)。结论　活血通脉片可抑制血浆ET过量释放 ,同时提高血浆CGRP浓度 ,具有良好的抗心肌缺血作用 ,对冠心病心绞痛有较好的疗效。Objectve To observe the effect of the HXTMT on serum ET and CGRP in angina patients. Methods Sixty patients were divided into Ⅰ orⅡgroup randomly. Patients ofⅠgroup(30 cases) were treated by HXTMT and general medicine,patients ofⅡgroup(30 cases) by common medicine, observing the change of the ET and CGRP in concentration before and after treatment, comparing the symptom and ECG with twenty healthy people.Results The concentration of ET ofⅠand Ⅱ group was higher than it in healthy people before treatment(P<0.01).CGRP was significantly inferior to the healthy people. But the Ⅰ group was superior to the Ⅱ group in general effect and ECG change.Conclusion The excess releasing of serum ET was constrained by HXTMT, meantime serum CGRP was increased by HXTMT.HXTMT there is good effect on cardiac muscles ischemia in angina of CHD.

关 键 词：活血通脉片 心绞痛 血浆内皮素 降钙素基因相关肽 心电图 

分 类 号：R541.4[医药卫生—心血管疾病]