复感宁方对复感儿T淋巴细胞亚群与白介素-2受体的影响  

The Znfluence of Fang Fuganning on T-lymphocyte subgroups and Soluble Interleukin 2 Receptor in childhood recurrent respiratory tract infection

作　　者：莫珊[1] 李宜瑞[2] 李伟元[1] 

机构地区：[1]佛山市中医院儿科,广东佛山528000 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《中医药学刊》2004年第9期1701-1702,共2页Study Journal of Traditional Chinese Medicine

摘　　要：儿童反复呼吸道感染是儿科临床的常见病 ,属中医学“虚人外感”的范畴。本病的病情反复、迁延难愈 ,病机错综复杂。近年来 ,该病与免疫功能的关系倍受重视 ,多数学者认为 ,免疫功能紊乱可能参与反复呼吸道感染的发生且影响其发展、预后。目前 ,小儿反复呼吸道感染的病因学研究更多集中在免疫功能异常方面 ,认为复感儿免疫功能低下是起病的根本原因。T淋巴细胞是由骨髓多能干细胞衍生的淋巴干细胞分化而来 ,并在胸腺内分化成熟而来。目的 :检测T淋巴细胞亚群和白介素 -2受体 (SIL -2R) ,探讨复感儿发病的免疫机理和复感宁方的疗效机理。应用健脾祛湿的复感宁方治疗 ,同时检测和比较患儿与正常儿童T淋巴细胞亚群和白介素 -2受体的差异 ,取得较满意的效果。方法 :分别以流式细胞分析法、化学发光免疫法检测正常儿童 2 2例及复感儿 2 8例用复感宁方治疗前后的T淋巴细胞亚群、SIL -2R的水平。分析三者相互的差异。结果 :治疗前复感儿的CD4 、CD4 /CD8水平明显低于正常儿童 (P <0 .0 1) ,CD8、SIL -2R水平明显高于正常儿童 (P <0 .0 1) ,CD3水平与正常儿童相比无统计学意义。以复感宁方治疗后 ,复感儿的CD4 、CD4 /CD8水平上升 (P <0 .0 1) ,CD8、SIL -2R水平下降 ,与治疗前比较均具有显著性差异 (P <0 .0 5 ,objective:To study the values of T-lymphocyte subgroups and Soluble Interleukin 2Receptor,and to explore the immune change of RRTI children and the action mechanism of Fuganning Fang.Methods:Adoption methods of APO-BRDU and Chemiluminescent Immunoassay,T-lymphocyte subgroups and soluble interleuckin 2 receptor(SIL-2R)were measured before treating and after treating in 28 cases of RRTI and 22 normal children.Results:There were very significant decline in CD 4 and CD 4/CD 8 level in RRTI children than in the normal(P<0.01),and significant higher in CD 8 SIL-2R level(P< 0.01) ,but no significant difference in CD 3.There were very significant higher in CD 4 and CD 4/CD 8(P<0.01),and significant decline in CD 8 and SIL-2R level at the end of the treatment(P<0.05,P<0.01),but no significant difference in CD 3,Conclusion:T-lymphocyte subgroups and SIL-2R may be involved in the etiology of RRTI and the Fang Fuganning can regulate the rate of T-lymphocyte subgroups and SIL-2R in RRTI children,so as to improve their immunologic function.

关 键 词：复感宁方 反复呼吸道感染儿童(复感儿) T淋巴细胞亚群 白介素-2受体(SIL-2R) 

分 类 号：R272[医药卫生—中医儿科学]