孕妇TORCH感染与胎儿畸形的关系  

Study of TORCH infection in pregnant women and fetal abnormalities

作　　者：刘瑾[1] 顾晓慧[2] 叶国玲[1] 赵晓岚[1] 张磊[1] 邬晋芳[1] 蔡小宁[1] 刘琦[1] 

机构地区：[1]西安交通大学第二医院妇产科医学遗传研究室,陕西西安710004 [2]西安交通大学医学院微生物学教研室,陕西西安710061

出　　处：《第四军医大学学报》2004年第18期1682-1685,共4页Journal of the Fourth Military Medical University

基　　金：陕西省科技研究发展计划项目 (2 0 0 1K1 0 G9)

摘　　要：目的 :探讨孕妇TORCH感染与胎儿畸形的关系 .方法 :采用酶联免疫吸附试验 (ELISA)法检测 10 0 0例孕妇血清TORCH的特异性抗体IgM ,对检测抗体阳性者和有畸胎史、不良孕产史的孕妇 ,用PCR法来检测TORCHDNA .结果 :孕妇TORCHIgM阳性率为 11.6 % ,其TOX ,RV ,HCMV ,HSVIgM阳性率分别为 3.6 0 % ,2 .5 0 % ,3.4 0 % ,2 .10 % ;母婴垂直传播率为 33.33% ,其中TOX ,RV ,HCMV ,HSV的垂直传播率分别为 4 3.33% ,2 6 .32 % ,34.6 2 % ,18.18% ;孕妇妊娠期间有上感症状者感染TORCHIgM阳性率 2 1.5 1%显著高于无上感症状者 9.34% (P <0 .0 1) ;有畸胎史TORCHIgM阳性率4 2 .10 %、不良孕产史 2 5 .4 0 % ,显著高于正常妊娠者 8.13% (P<0 .0 1) ;TORCH感染孕妇其胎儿畸形率 12 .37%显著高于无感染组 1.0 7% (P <0 .0 1) .结论 :孕妇TORCH感染是导致胎儿畸形的重要因素 .AIM: To study the relationship between TORCH infection in pregnant women and fetal abnormalities. METHODS: Enzyme linked immonosorbent assay (ELISA) was applied to detect TORCH IgM in the serum of 1000 pregnant women and TORCH DNA in the blood of pregnant women with TORCH IgM positive and abnormal pregnancy history was detected by polymerase chain reaction (PCR). RESULTS: The pregnant women TORCH IgM positive rate was 11.60%, TOX, RV, HCMV, HSVIgM positive rate was respectively 3.60%, 2.50%, 3.40% and 2.10%.The rate of TORCH intrauterine was 33.33% and that of TOX, RV, HCMV, HSV was respectively 43.33%, 26.32%, 34.62%, and 18.18%. The TORCH IgM positive rate of pregnant women with flu symptoms (21.51%) was significantly higher than that (9.34%) of women without flu symptoms (P<0.01). The TORCH IgM positive rate of pregnant women with fetal abnormality history (42.10%), or with abnormal pregnancy history (25.40%) was also significant higher than that (8.13%) of women with normal pregnancy(P<0.01). The rate of fetal abnormality (12.37%) in TORCH DNA positive group was significantly higher than that (1.07%) of negative group (P<0.01). CONCLUSION: TORCH infection in pregnant women is a factor causing fatal abortion and abnormalities.

关 键 词：妊娠 胎儿 TORCH感染 酶联免疫吸附测定 聚合酶链反应 

分 类 号：R714.53[医药卫生—妇产科学]