实验性糖尿病大鼠早期视网膜电图的变化  

Changes of electroretinogram in early-stage diabetic rats

作　　者：代海滨[1] 常耀明[1] 张作明[2] 丁振强[2] 李金声[1] 

机构地区：[1]第四军医大学航空航天医学系航空卫生与卫生勤务学教研室,陕西西安710033 [2]第四军医大学航空航天医学系航空临床医学教研室,陕西西安710033

出　　处：《第四军医大学学报》2004年第18期1710-1713,共4页Journal of the Fourth Military Medical University

摘　　要：目的 :观察实验性糖尿病早期对大鼠视网膜电图的影响 .方法 :链脲佐菌素诱导的糖尿病组大鼠和日龄相匹配的对照组正常大鼠 ,采用国际临床视觉电生理学会推荐的标准化方案 ,在糖尿病早期阶段 (5wk内 )对其进行杆细胞反应、最大反应、振荡电位、明适应视网膜电图和 2 0Hz闪烁反应 5个项目的检查 .结果 :在诱导糖尿病前和建模后 1wk时 ,糖尿病组大鼠与对照组相比未发现视网膜电图的异常 ;在建模后 2wk和 5wk时 ,糖尿病组杆细胞反应b波、最大反应b波、振荡电位O2 波和明适应视网膜电图b波的潜伏期都比对照组相应各波的潜伏期显著延长 ;两组大鼠各波的幅值始终未发现显著改变 .结论 :糖尿病大鼠在早期阶段杆细胞反应b波、最大反应b波、振荡电位O2 波和明适应视网膜电图b波的潜伏期显著延长 ,这有可能成为监测糖尿病视网膜病变早期发展的指标 .AIM: To observe the changes of electroretinogram of Sprague-Dawley rats with early-stage (within 5 weeks) diabetes. METHODS: According to standard program recommended by International Society for Clinical Visual Electrophysiology, we recorded the rod-response, max-response, oscillatory potentials (OPs), photopic electroretinograph (phot-ERG) and 20 Hz flicker response in early-stage diabetic rats induced by streptozotocin (STZ) and age-matched control ones. RESULTS: Before and at the first week after onset of diabetes, the ERG of diabetic rats did not differ significantly from that of control ones but at the second and fifth week, the implicit times of b wave of rod-response, b wave of max-response, O 2 wave of OPs and b wave of phot-ERG of diabetic rats were respectively prolonged significantly compared to those of control ones. However, no significant difference was found between the ERG amplitudes of diabetic rats and those of control ones. CONCLUSION: The observations indicate that the implicit times of b wave of rod-response, b wave of max-response, O 2 wave of OPs and b wave of phot-ERG are respectively prolonged significantly in early-stage diabetic rats, which can be used as indicators inspecting the early development of diabetic retinopathy.

关 键 词：视网膜电描记术 糖尿病视网膜病 链脲佐菌素 大鼠 

分 类 号：R339.14[医药卫生—人体生理学] R587.1[医药卫生—基础医学]