肥胖对血管内皮依赖性舒张功能的影响  

Effects of obesity on endothelium-dependent flow-mediated vasodilation function

作　　者：郭文彬[1] 刘宗明[2] 朱梅[1] 梁皓[1] 张蕾[1] 张楠[1] 

机构地区：[1]山东大学临床学院山东省立医院超声诊疗中心,山东济南250021 [2]山东省枣庄市立医院超声科,山东枣庄264001

出　　处：《医学影像学杂志》2004年第8期651-653,共3页Journal of Medical Imaging

摘　　要：目的 :用高分辨率超声评价单纯肥胖对血管内皮依赖性舒张功能的影响。方法 :用高分辨率超声检测 4 0例肥胖患者和 38例正常对照组肱动脉反应性充血和含服硝酸甘油后内径的变化。结果 :肥胖组肱动脉血流介导性血管扩张明显减弱 (10 .14± 6 .2 3) %对 (18.96± 6 .92 ) % ,P <0 .0 0 1,而两组对硝酸甘油的反应无显著性差异 (17.96± 6 .91) %对(19.0 1± 5 .81) % ,P >0 .0 5 ;肥胖组肱动脉血流介导性血管扩张与体重指数成负相关关系 (r=- 0 .6 1,P <0 .0 1)。结论 :肥胖患者存在血管内皮依赖性舒张功能障碍。Objective:To study the endothelium-dependent vasodilation function in patients with obesity.Methods:Forty patients with obesity and thirty eight age-matched normal controls were studied.Brachial diameter was measured with high-resolution ultrasound at rest,during reactive hyperemia and after sublingual nitroglycerin.Results:The increased percentage of brachial artery diameter at hyperemic condition was lower in patients comparing with those normal controls (10.14±6.23)% vs (18.96±6.92)%,P<0.001,whereas nitroglycerin-induced changes were not significant difference (17.96±6.91)% vs (19.01±5.81)%,P>0.05;The brachial endothelial function correlated negatively with BMI (r=-0.61,P<0.01).Conclusion:Endothelium-dependent vasodilation function was impaired in patients with obesity.

关 键 词：血管内皮功能 肥胖 超声检查 

分 类 号：R331.32[医药卫生—人体生理学] R445.1[医药卫生—基础医学]