非高血压左心室肥厚患者血清胰岛素水平的变化  

Changes of fasting serum insulin in normotensive patients with left ventricular hypertrophy

作　　者：王旭开[1] 杨成明[1] 王燕[1] 王红勇[1] 付春江[1] 方玉强[1] 石伟彬[1] 张晔[1] 杜文华[1] 李陶[1] 

机构地区：[1]第三军医大学大坪医院心血管内科,重庆400042

出　　处：《第一军医大学学报》2004年第9期1048-1050,共3页Journal of First Military Medical University

基　　金：国家自然科学基金(30170384)~~

摘　　要：目的探讨非高血压左心室肥厚(LVH)与血清胰岛素水平变化的关系。方法测定42例非高血压LVH患者的血清胰岛素、血糖和空腹血脂水平;用超声测定并计算心脏左室质量(LVM)和左室质量指数(LVMI),并按心脏超声测定分为非高血压LVH和左室正常组。结果LVH组的空腹血甘油三酯和胰岛素分别高于左室正常组,而胰岛素抵抗指数(HOMA法)高于左室正常组。直线相关分析显示非高血压LVH组HOMA指数与LVM、LVMI正相关(r=0.38、P<0.01及r= 0.29、P<0.01)。结论非高血压LVH患者的高胰岛素血症与LVH有密切相关,高胰岛素血症可能参与非高血压LVH的发生和发展。Objective To explore the relationship between left ventricular hypertrophy (LVH) and serum insulin changes in normotensive patients. Methods Forty-two normotensive patients with LVH, who were free of hypertension, coronary artery disease and diabetes, were examined for fasting serum insulin, glucose and serum lipids, and the left ventricular mass (LVM) and left ventricular mass index (LVMI) were also measured with echocardiography, with 46 normal subjects serving as the control group. Results The levels of fasting triglyceride and insulin, as well as insulin resistance index (IRI), were higher in the LVH group than in the control group. Multifactor regression analysis showed that IRI was positively correlated to LVM and LVMI in LVH group (r=0.38, P<0.01; r=0.29, P<0.01). Conclusion Hyperinsulinemia is closely correlated with LVH in these normotensive patients, and can be involved in the pathogenesis and progression of LVH.

关 键 词：左室肥厚 非高血压 胰岛素 血糖 甘油三酯 

分 类 号：R541.3[医药卫生—心血管疾病]