乌司他丁对严重烧伤大鼠血清中致炎因子的影响及意义  

Effects of ulinastatin on inflammatory cytokines in blood serum of rats after severe burn and the significance

作　　者：谢康[1] 黄跃生[1] 

机构地区：[1]第三军医大学西南医院全军烧伤研究所

出　　处：《第三军医大学学报》2004年第18期1643-1645,共3页Journal of Third Military Medical University

基　　金：国家重点基础研究发展规划资助项目 ("973"项目 ) (G19990 54 2 0 2 ) ;国家杰出青年科学基金资助项目 ( 30 12 50 4 0 ) ;全军"十五"指令性课题 ( 0 1L0 6 6 ) ;教育部高等学校骨干教师资助计划项目 ( 2 0 0 0 ) ;军队首批临床高新技术重大项目 ( 2 0 0

摘　　要：目的　探讨乌司他丁 (ulinastatin ,UTI)对严重烧伤大鼠血清中炎症因子的影响及意义。方法　建立大鼠烧伤模型 ( 3 0 %TBSAⅢ度烧伤 ) ,S D大鼠 96只随机分为单纯烧伤组 (B组 )和UTI处理组 (ulinastatin ,UTI组 )。在烧伤前及烧伤后 1、3、6、12和 2 4h检测血清中IL 1β、IL 6和TNF α3种细胞因子的含量。 结果　B组烧伤后 3hIL 1β、IL 6和TNF α开始明显升高 ,并分别于烧伤后 6h和 12h达到峰值。UTI组炎症因子升高幅度明显低于B组 (P <0 0 5 ) ,且于烧伤后 2 4h基本恢复正常。结论　UTI能明显减少烧伤大鼠血清中IL 1β、IL 6和TNF -α的含量 。Objective To study the effects of ulinastatin (UTI) on the inflammatory cytokines in the blood serum of rats after severe burn. Methods A total of 96 SD rats, inflicted with 30% TBSA full thickness skin burn, were randomly divided into simple burn group (group B) and UTI treated group (group UTI). The serum contents of IL 1β, IL 6, and TNF α were determined at 0, 1, 3, 6, 12, and 24 h before and after burn injury. Results In group B, the levels of serum IL 1β, IL 6, and TNF α were significantly higher at 3 h and peaked at 6 and 12 h after burn. In group UTI, the levels of serum IL 1β, IL 6, and TNF α were significantly lower than those in group B ( P <0.05). Conclusion UTI can decrease the production of IL 1β, IL 6, and TNF α in blood serum, retard the development and progression of burn injury, decrease the injury severity of inflammatory reaction by the cytokines.

关 键 词：乌司他丁 IL-1β IL-6 TNF—α 烧伤 

分 类 号：R392.11[医药卫生—免疫学] R644.02[医药卫生—基础医学]