压电石英晶体生物传感器的血浆凝血因子检测系统的效能研究  

A system for detection of blood coagulation factors using piezoelectric quartz crystal biosensor

作　　者：屈玲[1] 邓勇[2] 府伟灵[1] 

机构地区：[1]第三军医大学西南医院检验科,重庆400038 [2]上海交通大学自动化系,上海200030

出　　处：《第三军医大学学报》2004年第18期1661-1663,共3页Journal of Third Military Medical University

基　　金：国家"86 3"计划重大专项基金资助项目 ( 2 0 0 2AARZ2 0 2 3) ;国家"九五"科技攻关项目 ( 96 A2 3 0 4 0 4 ) ;国家自然科学基金资助项目( 30 2 70 388)~~

摘　　要：目的　研究用压电石英晶体传感器进行凝血因子检测的系统 ,介绍血浆凝血因子检测系统的工作原理。方法　利用压电石英晶体的逆压电反应 ,基于模糊和解耦控制技术 ,采用单片机进行恒温恒湿控制和频率计数 ,测得血浆凝集时间 ,来确定凝血因子的活性和含量。结果　本检测系统提高了凝血因子检测的方便性、精度和一致性。结论　压电石英晶体传感器用于凝血因子检测具有精度高和成本低等优点 。Objective To design a system for the detection of coagulation factors using piezoelectric quartz crystal (PQC) sensors and to introduce its operating principle and the main components. Methods The contrary piezoelectric response of quartz crystal was used. Based on the fuzzy and decoupling control, a singlechip computer was used for constant temperature and constant humidity control and frequency count. The plasma coagulation time was measured for the purpose of determination of the activities and contents of the coagulation factors. Results The system was convenient, precise, and consistent for the detection of the coagulation factors. Conclusion PQC sensors with high accuracy and low cost can be used in the detection of coagulation factors and has a bright future in clinical practice.

关 键 词：压电石英晶体 生物传感器 凝血因子 检测 系统 

分 类 号：R392-33[医药卫生—免疫学] R394-33[医药卫生—基础医学]