初诊急性淋巴细胞白血病患儿髓系抗原表达及临床意义  

Clinical significance of myeloid antigen expression in 152 children with acute lymphoblastic leukemia at first diagnosis.

作　　者：王菊香[1] 汤静燕[1] 顾龙君[1] 薛惠良[1] 陈静[1] 潘慈[1] 叶辉[1] 董璐[1] 

机构地区：[1]上海第二医科大学附属上海儿童医学中心

出　　处：《中国实用儿科杂志》2004年第9期535-537,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的　探讨儿童急性淋巴细胞白血病 (ALL)髓系抗原表达与预后及其他临床特征的关系。方法　流式细胞仪直接免疫荧光法检测上海儿童医学中心 1999年 1月至 2 0 0 2年 12月收治的初诊 15 2例ALL患儿髓系抗原表达。结果　 15 2例患儿中髓系抗原表达阳性率 18 4 % ,髓系抗原表达与性别、年龄、外周血白细胞数、FAB分型、免疫分型、染色体改变等无关。髓系抗原表达阳性与阴性ALL患儿的完全缓解 (CR)率分别为 96 2 %、95 7%(P >0 0 5 ) ,复发率为 16 7%、19 6 % (P >0 0 5 )。Objective To investigate the relationship between the expression of myeloid antigen in children with acute lymphoblastic leukemia and the prognosis.Methods The expression of myeloid antigen was measured in 152 patients using direct immunofluorescence scan.Results Of the 152 samples,28 were myeloid antigen positive(My + ).There was no correlation between myeloid antigen expression and initial characteristics such as sex 、age、 peripheral white blood cell counts、 FAB type、 immunophenotype or karyotype.In 152 acute lymphoblastic leukemia patients,the rate of first complete remission (CR) did not differ between My + and myeloid antigen negative(My )(96 2%,95 7%)patients (P>0 05),and the rate of relapse did not differ between My + and My (16 7%,19 6%)patients (P>0 05).Conclusion Myeloid antigen expression is not an independent prognostic factor in acute lymphoblastic leukemia patients.

关 键 词：白血病 淋巴细胞性 急性 分化抗原 

分 类 号：R72[医药卫生—儿科]