异丙醇衍生物β-受体阻断剂的合成及生物活性研究  

Synthesis and biological study of isopropanol derivatives as β-adrenergic blocking agent

作　　者：李子成[1] 郎淑霞[1] 向瑞礼[2] 陈淑华[3] 

机构地区：[1]四川大学化工学院,成都610065 [2]四川大学分析测试中心,成都610064 [3]四川大学化学学院,成都610064

出　　处：《西南民族大学学报（自然科学版）》2004年第5期577-580,共4页Journal of Southwest Minzu University(Natural Science Edition)

摘　　要：对甲氧基苯酚或对羟基苯甲酸乙酯在碱催化下与环氧氯丙烷反应生成环氧化物,然后再与各种胺反应得到胺基异丙醇衍生物,它们的结构经1HNMR、质谱和IR确证;测定了部分化合物的抗心率失常活性,结果表明所测定的化合物对心率失常均有一定的活性.p-methoxyphenol or ethyl p-hydroxybenzoate reacted with epichlorohydrin in the presence of base (NaOH), the obtained epoxy was then treated with different amines to give 2-propanol derivatives, their structures were determined by 1H NMR, mass spectrum and IR; antiarrhythmic activities of part compounds were determined, and the results showed that all detected compounds were active to arrhythmic.

关 键 词：异丙醇衍生物 Β-受体阻滞剂 抗心率失常 合成 

分 类 号：O623.42[理学—有机化学]