几种含钆MRI对照试剂的弛豫度与pH值关系研究  

pH Dependence of Relaxivities of Gadolinium MRI Contrast Agents

作　　者：谢狄霖[1] 陈忠[2] GORE John 

机构地区：[1]福建省医学测试重点实验室(福建省医学科学研究所),福建福州350001 [2]厦门大学化学系,建厦门361005 [3]耶鲁大学医学院,美国ct06510

出　　处：《分析测试学报》2004年第5期48-50,共3页Journal of Instrumental Analysis

基　　金：福建省自然科学基金资助项目(C0110024) ;国家自然科学基金资助项目(20172042)

摘　　要：测量了几种临床上常见的含钆磁共振成像对照试剂 ,包括马根维显 (Magnevist) ,普络显思(Prohance) ,欧乃影 (Omniscan)和三氯化钆 (GdCl3)的弛豫度随环境 pH值变化的曲线 ,讨论了它们的变化规律。Calculation of relaxivities of some gadolinium magnetic resonance imaging(MRI)contrast aˉgents,such as Magnevist,Prohance,and Omniscan,as well as GdCl 3 ,was performed on the basis of the measured NMR relaxation times.The curves of relaxivities of gadolinium chelate MRI contrast agents versus pH values were plotted.The variation trend,different pH dependence of chelates,and the relaxˉation mechanisms as well,were discussed.

关 键 词：核磁共振 对照试剂 弛豫度 PH值 

分 类 号：O614.339[理学—无机化学] O657.2[理学—化学]