新型非成瘾镇痛化合物Epibatidine 3-吡啶酯开链类似物的合成  

Synthesize the china 3-pyridyl ester analogs of anaddicted analgesic Epibatidine

作　　者：张传新[1] 凌翠霞[1] 

机构地区：[1]商丘师范学院化学系,河南商丘476000

出　　处：《商丘师范学院学报》2004年第5期90-94,共5页Journal of Shangqiu Normal University

基　　金：国家自然科学基金资助项目(29772004)

摘　　要：根据生物电子等排原理,以ABT-594为先导化合物,设计并通过DCC缩合反应合成了6个新的3 吡啶酯开链Epibatidine类似物,其结构经核磁共振谱、质谱、元素分析或高分辩质谱确证.Base on the lead compound ABT-594,2 and bioisosteric replancement,six new epibatidine analogs of 3-pyridy1 ester were designed and synthesized by DCC condensation.All of them was first reported and their structures confirmed by^1H and^(13)C NMR,elementary analysis,MS or HRMS.

关 键 词：EPIBATIDINE 非成癌镇痛 ABT-594 开链类似物 吡啶酯 合成 

分 类 号：O621[理学—有机化学]