通脉胶囊对动脉粥样硬化斑块稳定性影响的实验研究  

Experimental research on the effect of Tongmai Capsule for the stability of atherosclerotic plaque

作　　者：王强[1] 王毅[2] 

机构地区：[1]四川省中药研究所药理室,四川成都610041 [2]成都中医药大学附属医院病理科,四川成都610075

出　　处：《中成药》2004年第9期732-735,共4页Chinese Traditional Patent Medicine

摘　　要：目的 :通过分析基质金属蛋白酶 2 (MMP 2 )及其组织抑制因子 (TIMP 2 )在动脉粥样硬化 (AS)斑块组织中的表达 ,了解通脉胶囊 (当归、川芎、丹参、黄芪、党参等 )对动脉粥样硬化 (AS)斑块稳定性的作用。方法 :复制实验性家兔AS模型 ,实验结果后 ,取主动脉行组织形态学观察及斑块组织MMP 2、TIMP 2免疫组织化学分析。结果 :模型对照组MMP 2、TIMP 2表达明显高于正常对照组 ,但通脉胶囊组与模型对照组无明显差异 (P >0 .0 5 ) ,通脉胶囊对AS斑块稳定性的作用与MMP 2、TIMPAIM: To study the effect of Tongmai Capsule (Radix Angelicae Sinensis, Rhizoma Chuanxiong. Radix Salviae Miltiorrhizae, Radix Astragali, Radix Codonopsis, etc) on the stability of atherosclerotic plaque (AS) by analysing the expression of MMP-2 and TIMP-2. METHODS: After duplicating experimental rabbit's AS model, we fed the Asp-borne rabbit with Tongmai Capsule or distiled water, respectively, for 2 months, then took its aorta to observe the histomorphology and analyze the immunohistochemical test of MMP-2 and TIMP-2. RESULTS: There was no difference in MMP-2、TIMP-2 between Tongmai group and distiled water group (P>0.05). CONCLUSION: The results of the experiments showed that there was no certain relation between the effect of Tongmai Capsule on the stability of AS plaque and MMP-2、TIMP-2.

关 键 词：通脉胶囊 MMP-2 TIMP-2 家兔 

分 类 号：R285.5[医药卫生—中药学]