聚羟乙谷氨酰胺-5-氟尿嘧啶-1-乙酸的合成、表征与缓释性  

Synthesis and Characteristics of Poly[N-(2-Hydroxyethyl)-L-Glutamine]-5-Fluorouracil-1-Acetic Acid

作　　者：张静夏[1] 潘仕荣[2] 王琴梅[2] 黄爱东[1] 

机构地区：[1]中山大学中山医学院,广州510089 [2]中山大学附属第一医院,广州510089

出　　处：《应用化学》2004年第10期1057-1059,共3页Chinese Journal of Applied Chemistry

基　　金：广东省自然科学基金资助(031684)项目

摘　　要：Coupling water soluble and biodegradable poly( N (2 hydroxyethyl) L glutamine)(PHEG) synthesized from poly(( γ benzyl) L glutamine) and 2 aminoethanol with 5 fluorouracil 1 acetic acid(FUA) as a simulated drug affords a polymer prodrug poly( N (2 hydroxyethyl) L glutamine) 5 fluorouracil 1 acetic acid(PHEG FUA). The conjugation between the polymer and the drug compound has been confirmed by IR, UV, 1 H NMR and DSC. The content of 5 fluorouracil was determined to be about 26%(UV method). The in vitro test results show that the accumulated drug release amounts of PHEG FUA was 47 63% in phosphorus salt buffer solution(pH=7 2) during 120 h, indicating the conjugated compound has an obvious sustained release effect.Coupling water soluble and biodegradable poly( N (2 hydroxyethyl) L glutamine)(PHEG) synthesized from poly(( γ benzyl) L glutamine) and 2 aminoethanol with 5 fluorouracil 1 acetic acid(FUA) as a simulated drug affords a polymer prodrug poly( N (2 hydroxyethyl) L glutamine) 5 fluorouracil 1 acetic acid(PHEG FUA). The conjugation between the polymer and the drug compound has been confirmed by IR, UV, 1 H NMR and DSC. The content of 5 fluorouracil was determined to be about 26%(UV method). The in vitro test results show that the accumulated drug release amounts of PHEG FUA was 47 63% in phosphorus salt buffer solution(pH=7 2) during 120 h, indicating the conjugated compound has an obvious sustained release effect.

关 键 词：聚(N-(羟乙基)-L-谷酰胺)氟尿嘧啶乙酸 高分子前药 缓释 

分 类 号：O633.2[理学—高分子化学]