用单克隆抗体观察慢性肝炎患者细胞免疫状况的变化  

Studies on Cellular Immunity of Chronic Hepatitis patients with Monoclonal Antibodies

作　　者：封江南[1] 陈善华[1] 史良如[1] 姚启湘 马让 郭世保 俞建军 

机构地区：[1]卫生部武汉生物制品研究所免疫研究室 [2]空军汉口医院

出　　处：《免疫学杂志》1989年第2期47-50,共4页Immunological Journal

摘　　要：本文用多种单克隆抗体对32例慢性肝炎患者的细胞免疫状况进行了研究。结果发现患者肝组织内淋巴细胞和单核、巨噬细胞浸润明显增加,坏死区浸润细胞主要是T_3^+和T_8^+细胞。B淋巴细胞浸润极少,浸润淋巴细胞表面IL—2受体阳性细胞与外周血淋巴细胞表面IL—2受体阳性细胞率均无改变。患者外周血单个核细胞改变为T_3^+下降,T_4/T_8比例下降,单核、巨噬细胞、B淋巴细胞及淋巴细胞表面HLA—DR、DP、DQ标志与正常人无差异。Cellular immunity of 32 cases of chronic hepatitis B was investigated with monoclonal anti-lyphocyte antibodies. The results showed that the infiltration of lymphocytes and monocytes and macrophages in liver tissue from chronic hepatitis B patients increased apparently and that of piecemeal necrosis region was related mainly to T3, T8 positive cells, however there was only a few B+ lyphocytes in the region. There was do difference of percentages of infiltrating lymphocytes with IL-2 receptor between patients and normal control. The results for the determination of PBL from the patients showed that the percentage of T3+ cells decreased and so did the value of T4/T8.No changes of mo-nonnuclear, macrophages, B lymphocytes with HLA-DR, DP, DQ marker between the patients and normal control occured.

关 键 词：肝炎 单克隆抗体 细胞免疫 

分 类 号：R371.22[医药卫生—病原生物学]