3种梅毒血清学诊断方法在梅毒诊治中的应用价值  

The application value of three laboratory methods for the diagnosis and treatment of syphilis

作　　者：刘小平[1] 邓岩[2] 

机构地区：[1]安徽中医学院第一附属医院,安徽合肥230031 [2]安徽高等医学专科学校,安徽合肥230061

出　　处：《检验医学》2004年第4期310-311,共2页Laboratory Medicine

摘　　要：目的　探讨金标法、甲苯胺红不加热血清试验 (TRUST)、明胶颗粒凝集试验 (TPPA)检测各期梅毒的价值。方法　使用上述 3种方法测定了梅毒患者和健康对照组 ,比较 3种方法的假阴性率。结果　对于 4 3例梅毒患者血清的抗体测定 ,3种方法出现的假阴性率在梅毒各期不同。结论　Ⅰ期梅毒时应同时选金标法和TPPA ,金标法比TRUST更早出现阳性 ,抗体滴度低时结果更易观察。Ⅱ、Ⅲ期梅毒时 ,可选用TRUST和TP PA ,TRUST可避免前带现象 。Objective To study the value of immunoglod lablling technique(IGLT), toluidine red unheated serum reagin test(TRUST) and Treponema pallidum particle assay(TPPA) in the diagnosis and treatment of syphilis. Methods Serum antibodies in a with syphilis patient and in control were measured by these three methods. Results Sera of 43 patients with syphilis were measured the results of false negative rate were different in each syphilis term. Conclusions At primary syphilis IGLT and TPPA should be selected, postive result of IGLT appears earlier than TRUST, and is observed easily in lower titer antibody. At secondary and tertiary syphilis TRUST and TPPA may be selected. TRUST may avoid prozone phenomenon and be useful in the surveillance of syphilis treatment.

关 键 词：梅毒 血清学 甲苯胺红不加热血清试验 TRUST 明胶颗粒凝集试验 TPPA 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R446.11[医药卫生—临床医学]