胃舒散对四氯化碳慢性肝损伤大鼠的保护作用  

Protective Effect of Weishusan on Chronic Hepatic Injury Induced by CCL_4 in Rats

作　　者：林旭楷[1] 许森源 李德名 张奕鹏[1] 

机构地区：[1]汕头大学医学院第二附属医院,汕头市505041 [2]汕头市金石制药总厂,广东汕头515041 [3]汕头市金园区中医医院,广东汕头515031

出　　处：《医药论坛杂志》2004年第11期46-47,49,共3页Journal of Medical Forum

摘　　要：目的　观察胃舒散对四氯化碳 (CCl4)所致大鼠慢性肝损伤的影响。方法　采用CCl4诱导大鼠慢性肝损伤模型 ,测定血清丙氨酸氨基转移酶 (ALT)、天门冬氨酸氨基转移酶 (AST)、血清白蛋白 (ALB)、透明质酸(HA)、肝组织羟脯氨酸 (Hyp)含量 ,并进行肝脏病理组织学检查。结果　CCl4慢性肝损伤大鼠血清ALT、AST、HA、肝组织Hyp含量升高 (与正常组比较P <0 0 1～ 0 0 0 1) ,血清ALB含量降低 (与正常组比较P <0 0 1) ,肝细胞坏死程度和肝组织纤维化程度显著增加 ,造模成功。胃舒散能显著降低血清ALT、AST、HA、肝组织Hyp含量(与模型组比较P <0 0 5～ 0 0 1) ,升高血清ALB值 (与模型组比较P <0 0 5～ 0 0 1) ,并能使肝细胞坏死程度和肝组织纤维化程度减轻。结论　胃舒散对大鼠CCl4慢性肝损伤有明显的保护作用。Objective To observe the protective effects of Weishusan on chronic hepatic injury induced by CCl 4 in rats. Methods Rat model of chronic hepatic injury was made by CCl 4 The levels of serum AST、ALT、ALB、HA、Hyp and liver pathological tissue were observed.Results The level of serum ALT、AST、HA、Hyp in CCL 4 induced chronic hepatic injury rats all increased Conmpared with normal group(P<0.01～0.001)the level of serum ALB decreased(compared with normal group,P<0.01)Comparing model group with normal group the chronic hepatic injury rat model was proved to be established successfully. Compared with model group the dosage groups of Weishusan could descrease the serum ALT,AST, HA and the contents of Hyp (compared with model group, P<0.05～0.01),increase the level of serum ALB (compared with model group P<0.05～0.01) and reduce the range of hepatic pathologic change in rats.Conclusion Weishusan can protect rats from chronic heptic injury caused by CCl 4.

关 键 词：胃舒散 四氯化碳 慢性肝损伤 大鼠 保护作用 病理组织学 

分 类 号：R259.75[医药卫生—中西医结合]