丹参酮ⅡA对血管紧张素Ⅱ诱导的心肌细胞肥大、凋亡的影响  

The Effect of Tanshinone Ⅱ A on Hypertrophy and Apoptosis of Cardiomyocytes Induced by Angiotensin Ⅱ

作　　者：谢辉[1] 郑智[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院急诊科,湖北武汉430030

出　　处：《高血压杂志》2004年第4期359-361,共3页Chinese Journal of Hypertension

基　　金：湖北省科技攻关项目资助 (NO 2 0 0 2AA3 0 1C2 9)

摘　　要：目的　研究丹参酮ⅡA(TSN)对血管紧张素Ⅱ (AngⅡ )诱导的心肌细胞肥大、凋亡的影响。方法　培养乳鼠心肌细胞分别暴露于AngⅡ (10 -6mol/L)、TSN(10 -6mol/L、AngⅡ (10 -6mol/L) +TSN(10 -5mol/L) 36h ,检测心肌细胞的凋亡率、心肌细胞直径和3 H亮氨酸掺入率。结果　TSN可抑制AngⅡ所诱导的心肌细胞的凋亡率、心肌细胞直径和3 H亮氨酸掺入率的显著增高。结论　TSN可抑制AngⅡ所诱导的心肌细胞的凋亡和肥大。Objective To study the effect of tanshinone ⅡA (TSN)on hypertrophy and apoptosis of cardiomyocytes induced by Ang Ⅱ in vitro. Methods The cultured neonatal rat cardiomyocytes(NRCs) were treated with AngⅡ(10{-6} mol/L, TSN(10{-5} mol/L)and AngⅡ (10{-6} mol/L)TSN (10{-5} mol/L) respectively in free-serum medium for 36 h. The percenage of apoptoic myocytes, the cell size and {}3H-Leucine incorporation were investigated. Results The percenage of apoptoic myocytes, the cell size and protein synthesis rate of cardiomyocytes were increased significantly after Ang Ⅱ treatment. TSN inhibited these effect of Ang Ⅱ. Conclusion TSN prevent cardiomyocytes from hypertrophy and apoptosis induced by Ang Ⅱ.

关 键 词：丹参酮ⅡA 血管紧张素Ⅱ 心肌细胞肥大 心肌细胞凋亡 心肌肥厚 

分 类 号：R285[医药卫生—中药学]