吲达帕胺对高血压病左室肥厚及神经内分泌因素的影响  

The Effects of Indapamide on Left Ventricular Hypertrophy and Neurocrine Factors in the Patients with Essential Hypertension

作　　者：陆光华[1] 张美祥[1] 张依群 李培 王定胜[1] 卢源[3] 张小蕾[2] 

机构地区：[1]贵阳医学院内科学教研室 [2]贵州省老年医学研究所 [3]v内科学教研室

出　　处：《贵阳医学院学报》1993年第1期53-56,共4页Journal of Guiyang Medical College

摘　　要：本文报道吲达帕胺对30例高心病患者左室肥厚(LVH)、血压、总外周血管阻力(TPR)、血浆肾素-血管紧张素-醛固酮系统及血清儿茶酚胺的影响。经吲达帕胺治疗4周后,血压、TPR、室间隔和左室后壁厚度、左室质量及左室质量指数(LVMI)均显著降低,血浆肾素活性、血管紧张素Ⅱ及醛固酮浓度显著增高,而血清去甲肾上腺素和多巴胺浓度无显著变化。相关分析发现LVMI的下降与TPR的下降呈显著正相关。本研究表明吲达帕胺可逆转高血压病LVH,而TPR下降在其逆转中起着重要作用。The eifects of indapamide on blood pressure (BP), total peripheral resistance (TPR), left ventricular hypertrophy (LVH), the levels of plasma renin-angiotensin-aldosterone (RAA) system and serum catecholamines(CA) were investigated in thirty cases of essential hypertension with LVH. The results showed that the BP, TPR, interventricular septal and left ventricular posterior wall thickness, left ventricular mass and left ventricular mass index (LVMI) were decreased significantly, while the plasma levels of renin activity, angiotensin Ⅱ and aldosterone were increased significantly after indapamide treatment in the patients. However, there were no significant changes in serum concentrations of norepinephrine and dopamide. Linear regresion analysis showed that the change of LVMI was correlated significantly with the change of TPR (r=0.5465, P<0.01). This paper suggested that indapamide may regress LVH, and the decrease of TPR play an important role in its regression of LVH.

关 键 词：高血压 吲达帕胺 肾素 血管紧张素 

分 类 号：R544.105[医药卫生—心血管疾病]