慢性充血性心力衰竭大鼠动物模型制备  

A model in rat of chronic congestive heart failure

作　　者：赵英强[1] 孙兰军[1] 徐强[1] 李慧臻[1] 王保和[1] 

机构地区：[1]天津中医学院第二附属医院,天津300150

出　　处：《天津中医药》2004年第4期318-321,共4页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市科委自然基金项目资助(993606511)

摘　　要：[目的]研制慢性充血性心力衰竭大鼠动物模型。[方法]采用腹主动脉缩窄法制作慢性心衰大鼠模型 ,测定血液动力学指标 ,以确定慢性心衰模型成功。[结果]模型组心率 (HR)由 (381.000+52.359)次/min上升到(471.000±57.824)次/min(P<0.05) ;左室舒张时间 (LVET)由 (80.265 +24.021)ms缩短至 (52.546 +22.258)ms,每搏心输出量(SV)和每分心输出量(CO)均显著下降 (P<0.05) ,提示模型组大鼠手术后3周心脏功能明显下降 ,而对照组心功能各项指标均无变化。组间比较HR、LVET、CO、SV均有显著性差异(P<0.05)。[结论]模型组造模成功。同时 ,观察心衰大鼠临床表现明显 ,电镜下观察大鼠心肌有明显改变。Objective] To explore the preparation of the model of chronic congestive heart failure(CCHF)in rat.[Methods] The CCHF models was made by applying abdominal artery constriction.Whether successful or not in model producing was determined by testing the hemodynamic indexes.[Result] The HR in model group ascended from381.00±52.36per minute to471.00±57.84per minute(P<0.05);LEVT shortened from(80.27±24.02)ms to(52.55±22.26)ms.Both SV and CO descended significantly(P<0.05).It showed that the cardiac function descended obviously in model group3weeks after operation,while that in the control group had not any changes.The comparisons of HR,LVET,CO and SV between groups showed significant differences(P<0.05).[Conclusion]The model is made successfully.At the same time,obvious clinical syndromes in the CCHF rats are observed.Significant changes in the cardiac muscles of the rats can be observed electromicroscopically.

关 键 词：慢性充血性心力衰竭 大鼠 动物模型 制备 血液动力学 

分 类 号：R541.61[医药卫生—心血管疾病] R-33[医药卫生—内科学]