盐酸西替利嗪巴布剂的研制及体外释放特性  

Preparation of cetirizine HO cataplasm and its in vitro release aspect

作　　者：刘继勇[1] 胡晋红[1] 朱全刚[1] 孙华君[1] 

机构地区：[1]第二军医大学长海医院药学部,上海200433

出　　处：《中国新药杂志》2004年第7期616-619,共4页Chinese Journal of New Drugs

基　　金：中国人民解放军十五重点课题(01Z66)

摘　　要：目的:制备盐酸西替利嗪(CET)巴布剂并研究其体外释药性能和透皮吸收行为。方法:以水溶性高分子材料为基质制备CET巴布剂,采用HPLC法测定制剂中CET的含量。按2000年版中华人民共和国药典方法进行体外释放度的测定,利用Franz扩散池研究巴布剂的透皮吸收行为。结果:CET巴布剂含量稳定,体外释药符合Higuchi方程,释放速率为0.557 7mg·cm-2·h-1/2。透皮吸收符合零级动力学过程,渗透速率为14.58μg·cm-2·h-1。结论:CET巴布剂为皮肤控释型透皮给药系统,为临床治疗过敏性疾病提供了新的给药途径。Objective:To prepare cetirizine HC1 cataplasm and to study its in vitro release characteristics. Methods: The cetirizine HC1 cataplasm was prepared from a high molecular weight water-soluble material. Its content was determined by a HPLC method. Its in vitro release rate was measured by using method contained in Chinese Pharmacopeia 2000. Its transdermal absorption properties were studied by using Franz diffusion cell. Results: The cetirizine HC1 cataplasm prepared had a constant content. Its in vitro release property conformed to Higuchi equation with a release rate of 0. 557 7mg· cm -2·h -1/2. Its transdermal absorption met zero order dynamic process. Its permeable rate was 14.58 μg · cm -2 · h -1. Conclusion: The cetirizine HC1 cataplasm is a skin regulated transdermal therapeutic system with sustained release property.

关 键 词：盐酸西替利嗪 巴布剂 体外释放 透皮吸收 

分 类 号：R944.9[医药卫生—药剂学] R976[医药卫生—药学]