微量元素硒调节细胞信号传导的研究进展  

Progresses in Selenium-Modulating Cellular Signal Transduction

作　　者：廖海星[1] 丁尚林 胡德聪[3] 刘琼[3] 

机构地区：[1]长江大学化学与环境工程学院,湖北荆州434023 [2]化学工业出版社,北京100029 [3]华中科技大学化学系,湖北武汉430074

出　　处：《化学与生物工程》2004年第4期10-12,共3页Chemistry & Bioengineering

摘　　要：概述了硒调节细胞信号传导的功能,认为其调节信号通路有:促分裂原激活蛋白激酶信号通路、蛋白激酶C信号通路、核糖体S6蛋白激酶信号通路、转录因子NF-κB和AP-1等。同时认为氧化还原修饰信号分子是硒调节信号传导的主要机制。硒通过作用于信号传导通路而调节细胞的分化、生长、增殖和凋亡,使硒具有生物多样性。Functions of Selenium modulating cellular signal transduction have been interpreted systematically. The signal transduction pathways modulated by selenium are associated with the following signal molecules: mitogen activated protein kinase( MAPK), protein kinase C(PKC), ribosomal S6 protein kinase, nuclear factor NF-κB and AP-1. Selenium regulates the signals through their redox reactions. Selenium affects cellular differ-entiation, growth, proliferation and apoptosis by modulating signal transduction.

关 键 词：硒 信号传导 氧化还原 

分 类 号：Q507[生物学—生物化学] Q584