乙基纤维素固体分散体中5F释放度影响因素研究  

Investigation on the factors affecting dissolution of 5F from ethylcellulose solid dispersions

作　　者：李宝红[1] 张立坚[2] 东野广智[2] 邓亦峰[1] 梁念慈[1] 

机构地区：[1]广东医学院广东天然药物研究与开发重点实验室,广东湛江524023 [2]广东医学院分析中心,广东湛江524023

出　　处：《实用医药杂志》2004年第8期727-728,共2页Practical Journal of Medicine & Pharmacy

基　　金：国家自然科学基金项目(3987099);广东医学院青年基金(XQ0209)

摘　　要：目的制备不同乙基纤维素与5F固体分散体,并研究不同因素对5F溶出度的影响。方法溶剂法制备乙基纤维素固体分散体颗粒,测定其溶出度,考察各主要因素对5F释放的影响。结果乙基纤维素的黏度、含量、固体分散体的粒度、溶出介质的pH对药物释放均有影响。结论乙基纤维素可用来制备5F缓释固体分散体。Objective To prepare different 5F solid dispersions and study the factors affecting dissolution of 5F by using ethylcellulose as carrier. Methods Prepared ethylcellulose 5F solid dispersion granules by solvent method and determined the dissolution of the granules,so that the factors which affected dissolution of solid dispersion were investigated. Results The viscosity and quantity of ethylcellulose,the granule size of solid dispersion and the pH of the dissolution medium had all affected dissolution of 5F.Conclusion Ethylcellulose is suitable to be sustained release dispersion excipient.

关 键 词：乙基纤维素 5F 溶剂法 固体分散物 释放度 

分 类 号：R944.2[医药卫生—药剂学]