地方性氟病病区胎儿大脑氨基酸类和单胺类递质含量测定  

Detection of Amino-acid and Monoamine Neurotransmitters of the Brains of Human Fetuses from a Fluorosis Endemia

作　　者：董仲[1] 万昌武[1] 张小蕾 刘家骝 

机构地区：[1]贵阳医学院病理学教研室 [2]贵州省老年医学研究所

出　　处：《贵阳医学院学报》1993年第4期241-246,共6页Journal of Guiyang Medical College

基　　金：卫生部青年科学基金

摘　　要：测定了慢性氟中毒病区引产胎儿大脑五种氨基酸及三种单胺类递质含量。发现兴奋性氨基酸门冬氨酸明显低于非病区胎儿,抑制性氨基酸牛磺酸含量明显高于非病区胎儿,主要抑制脊髓的甘氨酸含量明显减少。单胺类递质中去甲肾上腺素明显下降,额、枕部5-羟色胺升高,顶部(中央前、后回)5-羟色胺降低。Five kinds of amino-acid neurotrasmitters and monoamine neurotransmitters of the brains of therapeutically aborted fetuses from an endemic-f luorosis region were detected with thin layer chromatography and double beam thin layer scanner method. The material from a non-endemic region serves as the control. The results showed that the exciting amino acid, asparagin lowered while the inhibitory one, taurine rose markedly. Glycine, a transmitter exerting an inhibitory effect on the spinal cord also decreased. As regards to the monoamines, the nor-epinephrine content decreased significantly while the 5-HT content was much higher than in the non-fluorotics fetuses. Besides, an increase of dopamine was noticed in the frontal lobe of the brains. The above findings should merit a large share of attension since they might result in some neuro-psychic abnormalities.

关 键 词：氟化物中毒 胎儿 脑 氨基酸 

分 类 号：R599.902[医药卫生—内科学]