冠心灵对冠脉血流量、心肌收缩力和心电活动的影响  

The effects of Guanxinling on coronary blood flow, contraction force of cardiac muscle and electrical activity of the heart

作　　者：陆红丽[1] 李慈珍[1] 刘远谋1 翁恩琪[2] 刘赟[2] 

机构地区：[1]上海第二医科大学生理学教研室,上海200025 [2]华东师范大学环境卫生系,上海200063

出　　处：《心脏杂志》2004年第4期323-326,共4页Chinese Heart Journal

基　　金：国家自然科学基金资助项目 ( No.3 0 2 70 498)

摘　　要：目的 :研究中药复方制剂冠心灵的心血管作用并初步探讨其作用机制。方法 :运用细胞内微电极技术、L angendorff离体心脏灌流和心率变异性功率谱分析等方法 ,研究冠心灵对心肌细胞动作电位的影响 ;观察其对冠脉血流量和心肌收缩力的作用 ;分析冠心灵对冠心病患者心率变异性的影响。结果 :冠心灵增强 Ca2 +跨膜内流 ;增加冠脉血流量和心肌收缩力 ;改善因缺血导致冠脉流量和心肌收缩力的下降 ;功率谱分析显示心迷走交感对心率的调控作用比升高。结论 :冠心灵有改善心肌缺血的作用。AIM: Observe the cardiovascular effects of guanxinling capsule and discuss the possible mechanism. METHODS: Conventional microelectrode technique and Langendorff-perfused guinea-pig hearts were used. After patient taking capsules of guanxinling for 3 months, ECG were recorded and analyzed with heart rate variability(HRV) power spectrum analysis. RESULTS: Guanxinling could increase the Ca 2+ inward current. Guanxinling could increase the coronary blood flow, enhance the strength of contraction of the heart without obviously changing the heart rate. Guanxinling could also antagonise the negative effects produced by mimic ischemia. The ratio of cardiac parasympathetic tone to sympathetic tone is significantly increased by guanxinling. CONCLUSION: It indicates that guanxinling can protect ischemic myocardium.

关 键 词：冠心灵 慢反应动作电位 Langendorff灌流 心率变异性 

分 类 号：R285.5[医药卫生—中药学]