6,7-二氢-5H-环戊烷并[b]吡啶的合成进展  

Progress in Synthesis of 6,7-Dihydro-5H-Cyclopenta Pyridine

作　　者：段学民[1] 韩娟[1] 陈立功[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072

出　　处：《精细化工中间体》2004年第4期8-11,共4页Fine Chemical Intermediates

摘　　要：6,7 二氢 5H 环戊烷并[b]吡啶具有抗溃疡、抗癌等重要生理活性,是合成头孢匹罗的重要原料。按热重排反应、催化脱水脱氢反应、Friedlander缩合反应、Grignard试剂环合反应、Diels Alder反应和1,5 二羰基化合物的环合等合成6,7 二氢 5H 环戊烷并[b]吡啶的反应类型进行分类,首次对其合成进展进行了全面的综述,认为以吡啶衍生物及1,5 二羰基化合物为原料合成6,7 二氢 5H 环戊烷并[b]吡啶的方法值得关注。dihydro-5H-cyclopenta pyridine, which is an important material of synthesizing cefpirom, exhibits various biological activities, such as antiulcer and anticancer activity. According to different synthesis style, including the thermal rearrangement, catalytic dehydration and/or dehydrogenation, Friedlander condensation reaction, Grignard reaction, Diels-Alder reaction and cyclization of 1,5-dicarbonyl compounds, etc., the synthesis of 6,7-dihydro-5H-cyclopentapyridine was reviewed for the first time in this paper. The synthetic methods, in which pyridine derivatives and 1,5-dicarbonyl compounds act as raw material, should be attended.

关 键 词：6 7-二氢-5H-环戊烷并[b]吡啶 合成 头孢匹罗 

分 类 号：O626.321[理学—有机化学]