抗肿瘤药氟达拉滨的合成  

Synthesis of Fludarabine

作　　者：张奎[1] 许燕红 

机构地区：[1]杭州电化集团研发中心,杭州310053 [2]杭州达康化工有限公司,杭州310018

出　　处：《精细化工中间体》2004年第4期33-35,41,共4页Fine Chemical Intermediates

摘　　要：以鸟苷为起始原料,将其6位的酮基和2位的氨基分别转换成氨基和氟,并将原来的呋喃糖部分转换成阿拉伯糖构型,成功地制备了氟达拉滨以及磷酸氟达拉滨。合成反应总收率为15.2%。A process for the production of fludarabine and fludarabine phosphate was provided, wherein the guanosine was employed as the starting material,which is subjected to conversion of the 6-keto and 2-amino group to 6-amino and 2-fluoro group respectively, and conversion of ribofuranosyl moiety to arabinofuranosyl moiety .The overall yield of the process is 15.2%.

关 键 词：氟达拉滨 磷酸氟达拉滨 鸟苷 合成 

分 类 号：TQ463.5[化学工程—制药化工]