法昔洛韦原料的合成工艺研究  

A Novel Synthesis Technology of Famciclovir

作　　者：金义翠[1] 

机构地区：[1]南京工业大学制药与生命科学学院,江苏南京210019

出　　处：《精细化工中间体》2004年第4期39-41,共3页Fine Chemical Intermediates

摘　　要：对法昔洛韦的生产工艺中的反应时间、温度、试剂的选择等进行探索、改进,使总收率从21%提高到30%,纯度达到99%以上,该工艺降低了生产成本,更适合工业化生产。Famciclovir is a kind of new antiviral drug, which has a wide market prospect. In view of the present problems in the synthesis of Famciclovir and a large amount of literature, the optimum technology including reaction time, temperature , reagent, etc was studied. The overall yield was raised from less than 21% to about 30%, and the purity reaches above 99% in improved method. The process has the advantage of lower cost, so it can meet the requirements of industrial production.

关 键 词：法昔洛韦 药物 工艺改进 反应时间 温度 试剂 抗病毒药物 

分 类 号：TQ46[化学工程—制药化工]