核因子-κB与缺血缺氧所致疾病的关系  

Relation between NF-κB and hypoxia-ischemia- caused diseases

作　　者：杜逸亭[1] 董文斌[1] 

机构地区：[1]四川泸州医学院附属医院新生儿科,四川泸州646000

出　　处：《国外医学（妇幼保健分册）》2004年第4期209-211,共3页Foreign Medical Sciences (Section of Maternal and Child Health)

基　　金：四川中医管理局重点科研基金资助项目 (2 0 0 2 39)

摘　　要：核因子 κB是细胞中一个重要转录调控因子 ,存在于多种类型的细胞中。机体组织器官受到缺血缺氧的创伤后 ,核因子 κB被激活 ,从胞浆中进入细胞核内 ,结合到被诱导基因启动子序列上的κB位点 ,诱导基因转录 ,参与缺血缺氧导致心脏 ,肾脏 ,脑等重要器官的损伤 ,乃至危及生命。Nuclear factor-κB(NF-κB) is an important transcription regulatory factor,and it exists in various kinds of cells.When the tissues and organs suffer hypoxia and ischemia, NF-κB is activated and gets into the nuclear from the cytoplasm, leading to nuclear translocation, and then it binds to K-B site on the sequence of promoters of the induced genes to induce transcription of them. It takes part in the injuries of some important organs such as heart, kidneys and brain. Even, it endanger the lives.

关 键 词：核因子-ΚB 缺血缺氧 

分 类 号：R722[医药卫生—儿科]