充血性心力衰竭患者血浆趋化因子水平变化的研究  

The Changes of Plasma Chemokines Levels in Patients with Congestive Heart Failure

作　　者：李爱华[1] 龚开政[1] 王顺娣[1] 孙晓宁[1] 严俊峰[1] 骆秋平[1] 张振刚[2] 凤以良[1] 

机构地区：[1]江苏省扬州市第一人民医院心血管内科东南大学心血管疾病研究所,江苏扬州225001 [2]扬州大学医学院临床医学系

出　　处：《中国医师杂志》2004年第9期1178-1180,共3页Journal of Chinese Physician

摘　　要：目的　探讨充血性心力衰竭 (CHF)患者血浆中趋化因子水平与心衰病情之间的关系。方法　分别采用酶联免疫吸附法及放免法测定 62例CHF患者 (NYHA分级为II～IV)血浆中单核细胞趋化蛋白 -1(MCP -1)及白细胞介素 -8(IL -8)的浓度。结果　CHF组血浆中MCP -1及IL -8水平较正常对照组明显升高 (P <0 0 1) ,且随心功能分级增加逐步升高 ,与心衰病因无关。血浆中MCP -1水平与左室射血分数、6分钟步行距离、生活质量评分呈显著负相关 (r=-0 42 2 ,-0 2 92 ,-0 42 1,P均 <0 0 5 ) ,与左室舒张末期直径呈显著正相关 (r =0 2 63 ,P <0 0 5 ) ,而IL -8仅与生活质量评分呈显著负相关 (r =-0 42 9,P <0 0 1)。结论　心衰时机体外周血浆中MCP -1及IL -8水平的升高是心衰时机体免疫激活的一个标志 。Objective To explore the relationship between the plasma level of chemokines and clinical condition in patients with congestive heart failure (CHF). Methods The plasma levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) were measured in 62 patients with CHF (NYHA II～IV) and 18 healthy control subjects by ELISA and RIA, respectively. Results The levels of MCP-1 and IL-8 were significantly higher in CHF group than those in control group, and had a gradual increase along with the increasing of NYHA functional class. The increase of the chemokines levels was independent on the cause of the heart failure. The plasma MCP-1 level was significantly correlated with left ventricular ejection fraction, 6-minite walk distance, quality of life scores, and left ventricular end diastolic diameter, respectively(r=-0 422, -0 292, -0 421, 0 263, all P<0 05), but IL-8 level was only negatively related to quality of life scores (r=-0 429, P<0 01). Conclusion The high plasma level of MCP-1 and IL-8 in patients with CHF might be a marker of immune activation and a new index associated with the severe degree of CHF.

关 键 词：充血性心力衰竭 血浆 趋化因子 病情 白细胞介素-8 单核细胞趋化蛋白-1 

分 类 号：R541.6[医药卫生—心血管疾病]