冠脉病变程度及CRP与轻度肾功能不全关系研究  

A Sutdy on the Relationship among the Severity of Coronary Disease,CRP and Mild Renal Dysfunction

作　　者：沈丽[1] 王一尘[1] 殷峻[2] 杨卫红[1] 袁惠敏[1] 杨琦[1] 

机构地区：[1]上海第二医科大学附属新华医院老年医学科,上海200092 [2]上海第二医科大学附属新华医院内分泌科,上海200092

出　　处：《中国医师杂志》2004年第9期1191-1192,共2页Journal of Chinese Physician

摘　　要：目的　探讨C反应蛋白 (CRP)和冠状动脉病变程度与轻度肾功能不全的关系。方法　心源性胸痛患者 64例行冠脉造影 ,以住院后首次血清肌酐 10 6μmol/l为临界 ,分为肾功能正常组及肾功能不全组 ,采用冠状动脉狭窄评分 (CAS)评价冠状动脉狭窄程度。分析CRP和冠脉狭窄程度与血清肌酐的定性及定量关系。结果　CRP及CAS在轻度肾功能不全组明显增高 (P <0 0 5 ,P <0 0 1) ;冠脉狭窄程度、CRP水平和血清肌酐正相关。结论　轻度肾功能不全可用于评估冠心病严重程度 ,其机制可能和肾功能下降时 。Objective To explore the relationship among the severity of coronary disease, c-reaction protein (CRP) and mild renal dysfunction. Methods 64 patients underwent coronary angiography were divided into two groups according to their serum creatinine (cr) levels: normal renal function(cr<106μmol/L) and mild renal dysfunction( cr≥106μmol/L). The severity of coronary stenosis was quantified in a modified Gensini score(CAS). The relationship between CRP, the severity of coronary stenosis and serum creatinine level was analyzed. Results Both CRP concentration and CAS value significantly increased in mild renal dysfunction group compared with normal renal function group(P<0 01, P<0 05, respectively). Serum creatinine level was positively correlated with the severity of coronary stenosis and CRP concentration. Conclusion Mild renal dysfunction can be used to evaluate the severity of coronary heart disease.

关 键 词：冠脉病变程度 CRP 轻度肾功能不全 C反应蛋白 心源性胸痛 

分 类 号：R543[医药卫生—心血管疾病]