血浆降钙素基因相关肽和内皮素改变在不稳定性心绞痛中的意义  

Significance of changes in plasma calcitonin gene-related peptide and endothelin in patients with unstable angina

作　　者：罗兴林[1] 魏宗德[1] 薛莉[1] 张光莹[1] 秦国芬[1] 陈良海[1] 莫余波[1] 

机构地区：[1]泸州医学院附属医院,泸洲646000

出　　处：《中国心血管杂志》1997年第4期218-220,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：应用放射免疫法测定40例不稳定性心绞痛(UA),25例稳定性心绞痛(SA)和26例正常人血浆降钙素基因相关肽(CGRP)及内皮素(ET)浓度,结果:UA患者心绞痛发作时CGRP、ET均明显高于SA发作时及正常对照组,但CGRP/ET比值显著降低,且恶化型>初发型>自发型,UA缓解时升高的CGRP、ET均显著下降,提示CGRP、ET变化对UA的发生具有重要的影响,并与其病变程度相关.The concentration of plasma calcitonin gene - related peptide(CGRP) and endothelin(ET) were measured by radioimmunoassay in 40 patients with unstable angina(UA), 25 patients with stable angina(SA) and 26 normal subjects. The results showed that the values of ET were markedly increased, the values of CGRP were mild increased , but CGRP/ET ratio decreased in UA patients compared with SA group when angina episoded and with control. Furthermore, the changs above were greatest in cases with progressive angina. greater in cases with initial angina and lowest in cases with spontaneous angina, whereas, increased CGRP and ET declined after relief of angina. The data indicated that imbalance of CGRP and ET may be a possible pathogenesis of UA and correlate with severness of coronary stenosis.

关 键 词：血浆 降钙素基因相关肽 内皮素 不稳定性心绞痛 放射免疫法 测定 

分 类 号：R541.4[医药卫生—心血管疾病]