4′-(6-溴己氧基)联苯-4-甲酸甲酯的合成  

Synthesis of Methyl 4′-(6-Bromohexyloxy) diphenyl-4-carboxlate

作　　者：杭德余[1] 章于川[1] 张彩云[1] 郑志[1] 

机构地区：[1]安徽大学化学化工学院,安徽合肥230039

出　　处：《精细化工》2004年第9期648-649,共2页Fine Chemicals

基　　金：安徽省教育厅自然科学基金项目(2003kj018)

摘　　要：4′ 羟基联苯 4 甲酸与甲醇反应,合成了4′ 羟基联苯 4 甲酸甲酯。后者与1,6 二溴己烷反应合成了目标化合物4′ (6 溴己氧基)联苯 4 甲酸甲酯,反应工艺条件为:以无水乙醇为溶剂,n(4′ 羟基联苯 4 甲酸甲酯)∶n(碳酸钾)∶n(1,6 二溴己烷)=1∶1 5∶3,80℃反应8h,收率达60 8%。两步总收率57 6%。目标化合物经IR,1HNMR和元素分析确证了分子结构。4′-Hydroxybiphenyl-4-carboxylic acid reacted with methanol to form methyl 4′-hydroxybiphenyl-4-carboxylate(Ⅰ).Ⅰ reacted with 1,6-dibromohexane(Ⅱ) to give methyl 4′-(6-bromohexyloxy) diphenyl-4-carboxlate(Ⅲ).Choosing ethyl alcohol as solvent,when n(Ⅰ)∶n(K_2CO_3)∶n(Ⅱ)=1.0∶1.5∶3.0,the second reaction was carried out at 80 ℃ for 8 h to give Ⅲ in 60.8% yield.Total yield of two steps was 57.6%.The structure of Ⅲ was confirmed by IR,~1HNMR and elementary analysis.

关 键 词：4′-羟基联苯-4-甲酸 4′-(6-溴己氧基)联苯-4-甲酸甲酯 高分子铁电液晶 

分 类 号：O625.66[理学—有机化学]