高同型半胱氨酸血症与肺血栓栓塞症和(或)深静脉血栓形成的关系  

Relationship between hyperhomocysteinemia and pulmonary thromboembolism and/or deep venous thrombosis in Chinese population

作　　者：王美堂[1] 胡秋敏[2] 李强[3] 康舟军[1] 

机构地区：[1]中国人民解放军第二军医大学长海医院急诊科,上海200433 [2]中国人民解放军第85医院呼吸科,上海200433 [3]中国人民解放军第二军医大学长海医院呼吸内科

出　　处：《中国急救医学》2004年第9期625-627,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的　探讨高同型半胱氨酸血症 (HHcy)及同型半胱氨酸 (Hcy)代谢中的相关因素与肺血栓栓塞症 (PTE)和(或 )深静脉血栓形成 (DVT)的关系 ,以便有效防治静脉血栓栓塞症 (VTE)的发生与复发。方法　用病例对照研究的方法对 5 8例既往确诊为VTE的患者及与其性别、年龄相匹配的 5 8例对照 ,调查流行病学危险因素 ,高效液相色谱分析法测定血浆中Hcy、蛋氨酸和半胱氨酸的浓度。结果　①血浆Hcy浓度在两组之间有显著性差异 (P <0 0 5 )。其OR值及其 95 %可信区间为1 5 (1 2 16～ 2 2 13)。但血浆蛋氨酸和半胱氨酸浓度在两组之间无显著性差异 (P >0 0 5 )。②血浆Hcy在病例组内DVT组、单纯PTE组和DVT合并PTE组之间无显著差异 (P >0 0 5 )。结论　HHcy是中国人群PTE和 (或 )DVT独立的危险因素。Objective To investigate the association between hyperhomocysteinemia,the factors associated with homocysteine metabolism and pulmonary thromboembolism(PTE)and/or deep venous thrombosis(DVT)in Chinese population.Methods In 58 patients with VTE and 58 controls whose sex and age matched with study group, epidemiological risk factors were surveyed,concentrations of plasma homocysteine were measured by high performance liquid chromatography (HPLC). Results ①The concentration of plasma homocysteine had significant difference between the study group and the controls〔 (odds ratio(OR)=15,95%CI:1216～2213)〕,but there was no significant difference in the concentration of plasma methionine and cysteine between cases and controls(P>005).②There was no significant difference in concentration of plasma homocysteine between DVT,PTE and PTE with DVT groups (P>005).Conclusion Hyperhomocysteinemia is an independent risk factor of PTE and/or DVT in Chinese population.

关 键 词：肺血栓栓塞症 深静脉血栓形成 高同型半胱氨酸血症 

分 类 号：R543.5[医药卫生—心血管疾病]