亚临床型甲状腺功能减退症对老年人认知功能的影响  

The cognitive impairment in older patients with subclinical hypothyroidism

作　　者：朱德发[1] 谭忠林[2] 庄骏[2] 周江宁[2] 

机构地区：[1]安徽医科大学第一附属医院干部病房,合肥230022 [2]中国科技大学生命科学院神经科学系,合肥230001

出　　处：《中国临床保健杂志》2004年第5期343-344,共2页Chinese Journal of Clinical Healthcare

基　　金：科技部 973项目 (G19990 0 5 4 )

摘　　要：目的　评价中老年亚临床型甲状腺功能减退症患者认知功能。方法　选取亚临床型甲状腺功能减退症患者 2 5名和年龄、性别、教育程度相匹配的正常人 2 5名为研究对象 ,应用简易精神状态测量表(MMSE)和剑桥老年人认知测定量表中国修订版 (CAMCOG C)检测两组的认知功能。结果　CAMCOG C方法检测显示亚临床型甲状腺功能减退症患者其总分 ,注意、记忆、感知亚测试分值显著低于对照组 ,2 5例患者中有 9例认知功能受到损害 ,用MMSE方法检测差异显著意义。结论　中老年亚临床型甲状腺功能减退症患者有认知功能损害 ,尤其表现为注意、记忆、感知功能的损伤 ,同时也提示CAMCOG C量表在亚临床型甲状腺功能减退症的检测方面敏感。Objective To evaluate the cognitive function of older patients with SCH(subclinic hypothyroidism).Methods The cognitive function of 25 SCH patients(age ranged from 51 to 76) and 25 age,sex,and education level matched healthy controls(age ranged from 50 to 78) were measured by MMSE(mini-mental status examination) and CAMCOG-C(Chinese version of cambridge cognitive examination) tests.Results The scores of total CAMCOG-C,as well as memory,attention and perception subtests of SCH group were significantly lower than those of control group,while there was no significant difference in MMSE scores between two groups.Conclusion Older SCH patients have the cognitive impairment,especially,memory,attention and perception impairment.CAMCOG is a more sensitive instrument than MMSE in examining the cognitive impairment in the older SCH patients.

关 键 词：亚临床型甲状腺功能减退症 认知功能 记忆 注意 感知 

分 类 号：R581[医药卫生—内分泌]