青霉胺预防术后腹腔粘连的实验研究  

The study of penicillamine’s effect on preventing intraperitoneal adhesion formation

作　　者：刘宪强[1] 张文同[2] 石焕[3] 

机构地区：[1]山东省济南市中心医院普外科,山东济南250013 [2]山东大学齐鲁医院小儿外科,山东济南250012 [3]山东大学齐鲁医院消化科,山东济南250012

出　　处：《中国现代普通外科进展》2004年第4期240-242,共3页Chinese Journal of Current Advances in General Surgery

基　　金：山东省自然科学基金资助项目 (Y2 0 0 3C18)

摘　　要：目的 :观察青霉胺预防腹腔粘连的疗效。方法 :将 80只昆明小鼠随机分为 4组 ,均于其右侧腹膜固定乳胶片一块 ,按预先设计分别用青酶胺、几丁糖、透明质酸钠和右旋糖酐进行不同处理后关腹 ,并给予相应喂养。术后 7d ,14d剖腹观察粘连情况 ,对粘连组织行免疫组化染色。结果 :4种实验用药对腹腔粘连都有一定的预防作用 ,3%青霉胺与几丁糖疗效基本相当 ,作用时间长、效果明显优于透明质酸钠和右旋糖酐 ,其中右旋糖酐的作用比较差。结论 :青霉胺腹腔留置预防腹腔粘连作用持久 。Objective:To study the effect of penicillamine on preventing intraperitoneal adhesion formation.Methods: 80 mice were randomly divided into 4 groups. The abdomen of any mice was opened and a plastisol was sewed in the right side of the peritoneum, after different medicinal solutions was injected, the abdominal cavity was closed. Re-laparotomy was performed at the 7th and 14th day after first operation,and examined the adhesion.The adhesion tissue was detected with immunohistochemical technique.Results:Detaining penicillamine (3%, 1 ml) in abdominal cavity was more effective than HA sodium and dextran, but as effective as chitosan.Conclusion:Detaining penicillamine in abdominal cavity is convenient and safe, and its effect of preventing intra-peritoneal adhesion formation is trustworthy.

关 键 词：青霉胺 腹腔粘连 小鼠 术后 

分 类 号：R619.9[医药卫生—外科学]