血塞通滴丸治疗中风(脉络瘀阻证)的临床研究  

Clinical efficacy and safety of xuesetong pill in the treatment of patients with stroke

作　　者：赵映前[1] 张方健[1] 巴元明[1] 胡有志[1] 向楠[1] 冯德勋[1] 石杰[1] 

机构地区：[1]湖北中医学院附属医院内科

出　　处：《中国临床药理学与治疗学》2004年第9期1023-1025,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :评价血塞通滴丸治疗中风病 (脉络瘀阻证 )的临床疗效与安全性。方法 :以血塞通片为对照 ,进行随机、双盲双模拟、阳性药平行对照、多中心临床试验。结果 :血塞通滴丸治疗中风患者的证候总有效率为 90 .3% ,中风病总有效率为 91.9%。在治疗 2、3、4周后对中医证候、中医证候总积分、中风病、和中风病总积分的改善优于对照组 (P <0 .0 5 )。血塞通滴丸的起效时间 (13.16± 4 .90d)明显优于对照组 (19.10± 6 .78d ,P <0 .0 1)。对血液流变学的各项指标疗效均不明显 ,两组无显著性差异 (P >0 .0 5 )。两组未见明显不良反应 ,一般体检项目 ,血、尿、粪常规 ,肝、肾功能试验前检查正常者试验后亦无异常。结论 :血塞通滴丸治疗中风病 (脉络瘀阻证 )具有安全、有效、起效快等特点。AIM: To observe the clinical efficacy and safety of xuesetong pill in the treatment of patients with stroke. METHODS: Xuesetong pill was observed in the paralleled-control, double-blind, and double-simulated clinical trail. RESULTS: Xuesetong pill significantly improved the symptom of patient with stroke. Its total effective rate to the symptom was up to 90.3%. After the treatment of xuesetong pill for 2,3, and 4 weeks, the improvement of traditional medicine symptom, total score of traditional medicine symptom, stroke and total score of stroke were superior to those in the control group (P< 0.05). Its latent period of efficacy was 13.16± 4.90 days, which was obviously superior to that in the control group ( 19.10± 6.78 days) (P< 0.01). No serious side effect was found in the two groups. CONCLUSION: Xuesetong pill has a characteristic of safe, effective, and fast in the treatment of patients with stroke.

关 键 词：血塞通滴丸 中风病 药物不良反应 

分 类 号：R969.4[医药卫生—药理学]