农村婴幼儿粪便中α1-抗胰蛋白酶作为肠道蛋白质丢失指标的评价  

The Value ofα1-antitrypsins in Assessing Intestinal Protein Loss in Healthy Infants' Feces in Rural Areas

作　　者：张水平[1] 刘黎明[1] 孙晓勉[2] 王懿[1] 周博[1] 杨媛媛[1] 郝炳华[3] 郑全庆[3] 贾梅[4] 

机构地区：[1]西安交通大学第一医院妇幼保健中心,西安710061 [2]西安交通大学第一医院儿科 [3]西安交通大学医学院 [4]中国雀巢有限公司医学部

出　　处：《中国临床营养杂志》2004年第3期169-171,共3页Chinese Journal of Clinical Nutrition

基　　金：瑞士婴幼儿营养国际合作项目(99001)

摘　　要：目的了解正常农村婴幼儿粪便中α1-抗胰蛋白酶水平并评价将其作为衡量母乳喂养婴幼儿肠道蛋白质丢失的指标。方法用随机整群抽样的方法对农村中已做过营养调查的55名18个月以内婴幼儿采用ELISA方法进行粪便中α1-抗胰蛋白酶及sIgA的检测。检测结果采用EPI软件进行数据录入,SPSS10.0软件进行统计分析。结果婴幼儿粪便中α1-抗胰蛋白酶的平均含量为(281.76±238.04)mg/L,1岁以内粪便中α1-抗胰蛋白酶含量随年龄的增加有下降的趋势,但各组间差异无显著性(F=1.059熏P>0.05);粪便中α1-抗胰蛋白酶的含量与粪便中sIgA的含量呈显著正相关(r=0.523熏P<0.001)。结论农村正常婴幼儿粪便中α1-抗胰蛋白酶的平均含量与国内外报道一致;以粪便中α1-抗胰蛋白酶的含量作为衡量母乳喂养期婴幼儿肠道蛋白质丢失的指标是不合适的,尤其对新生儿更不适用。Objective To investigate the level ofα1-antitrypsins in healthy infants' feces in rural areas and the value ofα1-antitrypsins in assessing intestinal protein loss,especially in breast-feeding infants.Methods55infants under18months were investigated by random cluster sampling.ELISA technique was used to determine the levels ofα1-antitrypsins and sIgA in feces.Data were inputted into computer by EPI software and analyzed with SPSS10.0software.Results The average content ofα1-antitrypsins in feces was(281.76±238.04)mg/L in infants.It declined along with increased months in infants under1year,but the difference was not significant among5groups(F=1.059,P>0.05).It had a significantly positive correlation with sIgA(r=0.523,P<0.001).Conclusions The level ofα1-antitrypsins in healthy infants' feces in rural areas coincides with other studies.The level ofα1-antitrypsins in infants' feces is not an appropriate indicator to assess intestinal protein loss in breast-feeding infants,especially in neonates.

关 键 词：婴幼儿 粪便 Α1-抗胰蛋白酶 

分 类 号：R446.6[医药卫生—诊断学]