不同生长阶段长爪沙鼠血清中氧化与抗氧化物质含量变化  

Changes of SOD, MDA and GSH-Px in Sera of Monglian Gerbils

作　　者：卢静[1] 于秋红[1] 冯高谦[1] 黄沛力[1] 

机构地区：[1]首都医科大学实验动物科学部,北京100054

出　　处：《中国实验动物学报》2004年第3期188-189,共2页Acta Laboratorium Animalis Scientia Sinica

摘　　要：目的　探讨不同生长阶段长爪沙鼠血清中氧化与抗氧作用机制。方法　选择 1月龄、3月龄、2 4月龄的长爪沙鼠各 16只 (雌雄各半 ) ,测定长爪沙鼠血清中超氧化物歧化酶 (SOD)、丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GsH -Px)。结果　丙二醛 (MDA)在 3月龄最低 ,谷胱甘肽过氧化物酶 (GsH -Px)在 3月龄最高 ;超氧化物歧化酶 (SOD)随着长爪沙鼠的月龄增长而升高。结论　在长爪沙鼠生长过程中谷胱甘肽过氧化物酶 (GsH -Px)的含量变化与丙二醛 (MDA)含量变化有直接关系 ,而超氧化物歧化酶 (SOD)含量变化与MDA含量变化没有直接关系。Objective To study the changes of SOD, MDA and GSH-Px in sera of Monglian gerbils.Methods The gerbils at the age of 1 month, 3 months and 24 months were used in the experiment, and the sera were collected for determining the SOD,MDA and GSH-Px. Results At the age of 3 months, MDA was the lowest, but GSH-Px was the highest, while the SOD was ascending with growing. Conclusion The changes of GSH-Px showed the direct relation to MDA, while the changes of the SOD was irrespective to the changes of MDA.

关 键 词：生长阶段 长爪沙鼠 血清 氧化 超氧化物歧化酶 谷胱甘肽过氧化酶 

分 类 号：Q95-331[生物学—动物学] Q55