细胞因子信号转导抑制因子SOCS-3在成年大鼠视网膜内的定位分布  

CELLULAR LOCALIZATION OF SUPPRESSOR OF CYTOKINE SIGNALING-3 IN ADULT RAT RETINA

作　　者：刘猛[1] 赵靖[1] 石献忠[1] 于恩华[1] 

机构地区：[1]北京大学医学部解剖学系,北京,100083

出　　处：《解剖学报》2004年第4期437-439,共3页Acta Anatomica Sinica

基　　金：北京市自然科学基金资助 ( 70 2 2 0 18) ;北京大学2 0 0 1 985青年科研启动基金资助项目

摘　　要：目的分析JAK STAT信号转导途径抑制蛋白SOCS-3在大鼠视网膜内的基础表达和细胞内定位分布。方法免疫细胞化学技术。结果SOCS-3免疫阳性反应细胞广泛分布在视网膜节细胞层和内核层。在节细胞层,SOCS-3免疫阳性反应产物主要分布在节细胞核;在内核层,部分阳性细胞为Mｌｌｅｒ细胞。结论OCS-3在正常大鼠视网膜神经元及胶质细胞内有较为广泛的基础表达,并以核蛋白为其主要存在形式。Objective To study the basic expression and cellular localization of SOCS-3 in normal rat retina. Methods Neuro-immunocytochemistry techniques were used. Results SOCS-3 positive cells were widely distributed in the ganglion cell layer (GCL) and inner nuclear layer (INL) in the retina. In the GCL, SOCS-3 immunoreactivity was mainly in the neuclei of the ganglion cells.Some of the SOCS-3 positive cells in INL were Müller cells.Conclusion Basal expression of SOCS-3 is widely present in the neurons and glia in normal adult rat retina and mainly in the form of nuclear protein.

关 键 词：细胞因子信号转导抑制因子 Janus激酶.信号转导子与转录激活子 视网膜 大鼠 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学]