黏蛋白MUC-1在人胚胎胃黏膜发育中的阶段表达  

MUC-1 EXPRESSION IN GASTRIC MUCOSA OF HUMAN FETUSES

作　　者：苏丽英[1] 王慧娟[1] 张雷[1] 李陈莉[1] 

机构地区：[1]河北医科大学组织学与胚胎学教研室,石家庄050017

出　　处：《解剖学报》2004年第4期446-448,共3页Acta Anatomica Sinica

摘　　要：目的　阐明MUC 1在胎儿胃黏膜的表达特点 ,探讨MUC 1与胃上皮分化的关系。　方法　应用HE染色和SP免疫组织化学方法 ,检测 2 2例 9～ 30周胎儿胃黏膜的发育以及MUC 1在不同时期的表达。　结果　胎儿胃黏膜的分化可分为 3个不同时期 :1 在未分化期MUC 1呈极性分布于早期胃上皮的游离面。 2 在分化期MUC 1呈极性和弥漫性分布于中期胃黏膜上皮和腺上皮。 3 生长期MUC 1分布于胃底腺上皮。　结论　MUC 1的表达与胃上皮的分化密切相关。Objective To explore the expression of MUC-1 (one mucin) in the gastric mucosa of human fetus at different developmental stages and elucidate the relationship between MUC-1 expression and the cytodifferentiation of gastric epithelia. Methods HE staining and immunohistochemistry methods were used. Results The differentiation of the fetal gastric epithelial cells could be divided into three stages, the undifferentiated (S1), the differentiating (S2), and the growing stages (S3). MUC-1 appeared in cell apex of all undifferentiated cells in S1. In S2, MUC-1 appeared in cell apex and cytoplasm in the differentiating cuboidal epithelial cells.In the S3, MUC-1 focused on the glands, especially in the basal cells of glands.Conclusion There was different expression of MUC-1 at various developmental stages of gastric epithelia.

关 键 词：黏蛋白-1 细胞分化 胃 免疫组织化学 胎儿 

分 类 号：R329.1[医药卫生—人体解剖和组织胚胎学]