脑心通滴丸的活血化瘀作用及对心脑缺血的影响  

Effects of Naoxintong Drip Pill in Activating Blood and Removing Blood-stasis and on Myocardial and Cerebral Ischemia

作　　者：李元静[1] 吴燕敏[1] 芮菁[1] 刘云[1] 

机构地区：[1]天津市药品检验所,天津300074

出　　处：《中药新药与临床药理》2004年第5期326-330,共5页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的观察脑心通滴丸的活血化瘀作用及对实验性心脑缺血的影响。方法采用体内血栓、血小板聚集、血黏度、微循环、心脑缺血及局灶性脑梗塞等模型,观察脑心通滴丸的药效作用。结果脑心通滴丸能明显抑制大鼠血小板血栓形成和血小板最大聚集率,降低血瘀模型大鼠全血黏度、血浆黏度;还可增加小鼠耳廓微循环,延长小鼠脑循环障碍存活时间,改善心肌缺血大鼠心电图,对大鼠局灶性脑梗塞面积和行为障碍有明显的保护作用。结论脑心通滴丸具有活血化瘀,改善心脑缺血和局灶性脑梗塞作用。Objective To investigate effects of Naoxintong drip pill (NDP) in activating blood and removing blood-stasis and on myocardial and cerebral ischemia. Methods The in-vivo effect of NDP on thrombosis, aggregation of platelets, blood viscosity, microcirculation, acute myocardial and cerebral ischmia and the focal cerebral-infarction were observed for study the pharmacodyamic effect of NDP. Results NDP could significantly inhibit the formation of thrombosis and maximal aggregation rate of platelets, and decrease viscosity in whole blood and plasma in rats with blood stasis. It could also promote auricular microcirculation, prolong the survival time of mice with cerebral ischemia, improve the electrocardiogram of ischemic rats, reduce the focal cerebral-infarction area and improve behavior disorder. Conclusion NDP possesses actions of activating blood and removing blood-stasis and improving myocardial and cerebral ischemia and focal cerebral-infarction.

关 键 词：脑心通滴丸 药理学 体内血栓 血液流变学 心脑缺血 

分 类 号：R285.5[医药卫生—中药学]