中药肝复康对实验性肝纤维化大鼠肝功能及血清标志物的影响  

Effect of Ganfukang on Liver Function and Serum Hepatic Fibrosis Markers Levels in SD Rats with Experimental Hepatic Fibrosis

作　　者：车颖[1] 王善菊[2] 徐婷婷[3] 姜妙娜[3] 贾玉杰[3] 

机构地区：[1]大连医科大学附属第一医院,116011 [2]大连医科大学附属第二医院,116027 [3]大连医科大学病生教研室,116027

出　　处：《放射免疫学杂志》2004年第4期283-284,共2页Journal of Radioimmanology

摘　　要：目的 :研究肝复康对实验性肝纤维化大鼠肝功能及血清标志物的影响。方法 :采用四氯化碳致大鼠肝纤维化模型 ,经肝复康干预后分别以赖氏法、溴甲酚绿比色法测定血清转氨酶及白蛋白、球蛋白活性 ,放免法测定血清透明质酸 (HA)、层粘连蛋白 (LN)、Ⅳ型胶原 (C -Ⅳ )、Ⅲ型前胶原 (PC -Ⅲ )。结果 :肝复康治疗后血清转氨酶、球蛋白活性降低 ,白蛋白活性升高 ,血清HA、LN、C -Ⅳ、PC -Ⅲ均有明显降低 ,与模型组比较有显著差异 (P <0 .0 1 )。结论 :肝复康对实验性肝纤维化有明确的治疗作用 ,降低肝纤维化程度 ,同时有效减轻肝细胞损伤 ,改善肝功能。Objective To observe the effect of Ganfukang on liver function and serum hepatic fibrosis markers levels in SD rats with experimental hepatic fibrosis. Methods SD rat models of liver fibrosis was induced by CCl 4 ( n=57 ). Liver function (GPT,GOT) and serum hepatic fibrosis markers levels (HA, LN, 、C-Ⅳ、PC-Ⅲ, with RIA) were tested in these models and 10 control rats. Eleven model rats were left untreated, the others were treated with Ganfukang of different concentrations and the above hepatic paramters were again determined after completion of treatment. Results Lever function was much deteriorated and serum markers levels significantly increased in the model rats (vs controls, P <0.01). After treatment with GanFnkang, the improvement was significant (vs untreated models, P <0.01). Conclusion Ganfukang is of definite therapeutic value for experimental hepatic fibrosis in rat models.

关 键 词：中药 肝复康 实验性肝纤维化 大鼠 肝功能 血清标志物 

分 类 号：R259.752[医药卫生—中西医结合]