(+)-N-苄基氯化辛可宁的微波合成及其在(±)-BINOL拆分上的应用  

Synthesis of (+)-N-benzylcinchoninium chloride under microwave irradiation and its application in the resolution of (±)-BINOL

作　　者：丁盈红[1] 梁香[1] 张广文[1] 陈亚兴[1] 

机构地区：[1]广东药学院药学系,广东广州510224

出　　处：《化学试剂》2004年第4期241-242,共2页Chemical Reagents

摘　　要：采用微波常压合成法,控制温度条件下,快速制备了(+)N苄基氯化辛可宁,将其用于拆分1,1′联2萘酚外消旋体(BINOL),得R(+)BINOL收率60%,S(-)BINOL收率70%,效果良好。The mixture of benzyl chloride and cinchonine was heated at 100～104℃in DMF for about 15min under microwave irradiation to give(+) N benzylcinchoninium chloride in 55 1% yield,the efficient resolution of racemic BINOL has been achieved with (+) N benzylcinchoninium chloride.

关 键 词：(+)-N-苄基氯化辛可宁 微波合成 拆分 季铵盐 1 1′-联-2-萘酚外消旋体 

分 类 号：O643.36[理学—物理化学]