艾司唑仑荷移反应及分析应用  

Ultraviolt Spectrum Characteristics of Estazolam-Chloranil Charge Transfer Reaction and Its Application

作　　者：杜黎明[1] 卫侠[1] 

机构地区：[1]山西师范大学分析测试中心,临汾041004

出　　处：《分析化学》2004年第9期1213-1215,共3页Chinese Journal of Analytical Chemistry

基　　金：山西省自然科学基金资助课题 (No .2 0 0 410 3 0 )

摘　　要：采用紫外分光光度法研究了π电子受体四氯对苯醌 (TCBQ)与电子给予体艾司唑仑的荷移反应 ,结果表明 ,TCBQ与艾司唑仑在pH 8.2的BR缓冲溶液中能形成稳定的荷移反应络合物 ,吸光度显著增强。据此建立了测定艾司唑仑的简单、快速、准确和灵敏的方法。艾司唑仑浓度在 0 .2～ 3 .2mg/L范围内符合比尔定律。r=0 .9992。荷移络合物在 3 1 6nm处的表观摩尔吸光系数为 8.5× 1 0 4L·mol-1·cm-1。方法用于片剂中艾司唑仑含量的测定 ,其回收率为 99.2 %～ 99.7% ;相对标准偏差为 0 .7%～2 .1 %。The charge-transfer (CT) reaction between chloranil (TCBQ) as a pi-electron acceptor and estazolam (ESL) as electron donors was studied by using ultraviolt spectrophotometric method. Experiment shows that estazolam reacts with TCBQ in pH 8.2 Britton Robinson medium to form a stable CT complex which has higher absorption than ESL. Therefore a simple, rapid, accurate and sensitive method for the determination of ESL has been developed. Beer's law is obeyed in the range of 0.2 similar to 3.2 mg/L of ESL and r = 0.9992. The apparent molar. absorptivity of CT complexes at 316 nm is 8.5 x 10(4) L . mol(-1) . cm(-1). The composition of CT complex is found to be 1: 1 by Bent-French and curved intersection methods. The proposed method has been applied to the determination of ESL in tablets. The recoveries are 99.2% similar to 99.7%. The relative standard-deviation is 0.7% similar to2.1%.

关 键 词：艾司唑仑 荷移反应 含量测定 片剂 紫外分光光度法 四氯对苯醌 抗癫痫药物 

分 类 号：O657.3[理学—分析化学]