傅里叶变换中红外光谱技术用于人体胃镜样品检测的新方法  

New Detection Method of Gastric Endoscope Samples Using Fourier Transform Mid-spectroscopy

作　　者：李庆波[1] 孙学军[2] 张元福[1] 徐怡庄[1] 杨丽敏[1] 石景森[2] 吴瑾光[1] 

机构地区：[1]北京大学化学与分子工程学院 [2]西安交通大学第一医院,西安710061

出　　处：《高等学校化学学报》2004年第9期1624-1627,共4页Chemical Journal of Chinese Universities

基　　金：国家重点基础研究发展计划项目 (批准号 :2 0 0 2 CCA 0 190 0 );国家自然科学基金 (批准号 :3 0 3 7160 4;5 0 2 0 3 0 0 1;2 0 1710 0 4)和教育部博士学科点基金资助

摘　　要：应用傅里叶变换红外光谱 ( FTIR)测定了 1 84例胃镜样品 ,总结不同病变类型组织的光谱特征 ,并与病理结果进行比较 .实验结果表明 ,由于不同类型病变组织会在其分子组成和结构上发生相应改变 ,浅表性胃炎、萎缩性胃炎和胃癌组织具有不同的 FTIR光谱 ,可据此进行胃镜样品疾病类型和病变程度的判别 .研究结果表明 ,FTIR技术有望发展成为一种用于胃镜样品无创、快速、准确的在体临床诊断的新方法 .A new detection method of gastric endoscope samples with promising perspective in clinical application was first proposed in this paper. The identification of stomach cancer, chronic atrophic gastritis and superficial gastritis for a total of 184 gastric endoscope samples was first investigated by using Fourier transform mid-infrared spectroscopy. The spectral characteristics for different classifications of gastric tissues were summarized and correlated with the corresponding pathological results. The experimental results indicated that the changes of molecular composition and structure with various diseases of stomach tissues occur, so the distinct differences were observed among the FTIR spectra of the normal, atrophic gastritis, superficial gastritis and malignant gastric tissues, which were used to classify the diseases and determine the degree of diseases of the gastric endoscope samples. The results demonstrate that FTIR method possesses promising perspective to be developed as a new non-invasive, rapid, accurate and in vivo gastric endoscope detection technique in clinical application.

关 键 词：傅里叶变换中红外光谱 胃镜 光谱分析 红外检测 

分 类 号：O653[理学—分析化学]