含有异噁唑的S-三唑[3,4-b]-1,3,4-噻二嗪、咪唑[2,1-b]-1,3,4-噻二唑和咪唑[2,1-b]-1,3,4-噁二唑衍生物的合成  

Synthesis of S-Triazolo-1,3,4-thiadiazine, Imidazolo- 1,3,4-thiadiazole and Imidazolo-1,3,4-oxadiazole Derivatives Containing Isoxazole

作　　者：刘方明[1] 阿布拉江.克依木 王厚勇[3] 邵玲[3] 

机构地区：[1]杭州师范学院化学系,杭州310012 [2]中国医学科学院中国协和医科大学药物研究所,北京100050 [3]新疆大学化学与化工学院,乌鲁木齐830046

出　　处：《高等学校化学学报》2004年第9期1673-1675,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 970 2 0 0 7;2 0 162 0 0 4)资助

摘　　要：Isoxazole derivatives were characterized by broad spectrum of biological activities, but the condensed heterocyclic compounds containing isoxazole were scarcely reported. In this paper, we studied the 1,3-dipolar cycloaddition of p-methoxybenzohydroxamoyl chloride with ethyl sodioacetoacetate to obtain a key intermediate 2. Through compound 2, fifteen novel S-triazolo-1,3,4-thiadiazines(5a-5e), imidazolo-1,3,4-thiadiazoles(9a-9e) and imidazolo-1,3,4-oxadiazoles(10a-10e) containing isoxazole, which have potentially useful biological activities, were synthesized. The structures of the products were confirmed by elemental analyses and spectral analysis. And the characteristic data of IR, 1H NMR and MS were explained reasonably.Isoxazole derivatives were characterized by broad spectrum of biological activities, but the condensed heterocyclic compounds containing isoxazole were scarcely reported. In this paper, we studied the 1,3-dipolar cycloaddition of p-methoxybenzohydroxamoyl chloride with ethyl sodioacetoacetate to obtain a key intermediate 2. Through compound 2, fifteen novel S-triazolo-1,3,4-thiadiazines(5a-5e), imidazolo-1,3,4-thiadiazoles(9a-9e) and imidazolo-1,3,4-oxadiazoles(10a-10e) containing isoxazole, which have potentially useful biological activities, were synthesized. The structures of the products were confirmed by elemental analyses and spectral analysis. And the characteristic data of IR, 1H NMR and MS were explained reasonably.

关 键 词：异噁唑 均三唑并噻二嗪 咪唑[2 1-b]-1 3 4-噻二唑 咪唑[2 1-b]-1 3 4-噁二唑 

分 类 号：O626[理学—有机化学]